A SARS-CoV-2 protein interaction map reveals targets for drug repurposing

DE Gordon, GM Jang, M Bouhaddou, J Xu, K Obernier… - Nature, 2020 - nature.com
A newly described coronavirus named severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2), which is the causative agent of coronavirus disease 2019 (COVID-19), has …

[HTML][HTML] The global phosphorylation landscape of SARS-CoV-2 infection

M Bouhaddou, D Memon, B Meyer, KM White… - Cell, 2020 - cell.com
The causative agent of the coronavirus disease 2019 (COVID-19) pandemic, severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2), has infected millions and killed …

Benchmarking substrate-based kinase activity inference using phosphoproteomic data

C Hernandez-Armenta, D Ochoa, E Gonçalves… - …, 2017 - academic.oup.com
Motivation Phosphoproteomic experiments are increasingly used to study the changes in
signaling occurring across different conditions. It has been proposed that changes in …

[HTML][HTML] Meiotic nuclear pore complex remodeling provides key insights into nuclear basket organization

GA King, R Wettstein, JM Varberg, K Chetlapalli… - Journal of Cell …, 2023 - rupress.org
Nuclear pore complexes (NPCs) are large proteinaceous assemblies that mediate nuclear
compartmentalization. NPCs undergo large-scale structural rearrangements during mitosis …

Proteomics-based detection of immune dysfunction in an elite adventure athlete trekking across the Antarctica

DC Nieman, AJ Groen, A Pugachev, AJ Simonson… - Proteomes, 2020 - mdpi.com
Proteomics monitoring of an elite adventure athlete (age 33 years) was conducted over a 28-
week period that culminated in the successful, solo, unassisted, and unsupported two month …

Statistical methods to infer kinase activities and kinase-substrate interactions using phosphoproteomic data

CI Hernandez Armenta - 2020 - repository.cam.ac.uk
The activity of kinases play an important role during cell signalling. They phosphorylate
proteins to regulate their interactions, structural conformation, cell location and enzymatic …

Association between apolipoprotein E variants and obesity-related traits in Mexican school children

Y Rodríguez-Carmona, M Pérez-Rodríguez… - Lifestyle …, 2015 - karger.com
Abstract Background/Aim: Genetic variation in apolipoprotein E (ApoE) has a key role in lipid
metabolism. However, its contribution to the amount and distribution of body fat is under …

A 3-state model for multidimensional genomic data integration

K Baca-Lopez, MD Correa-Rodriguez… - Systems …, 2013 - Taylor & Francis
Background: Genomic technologies have allowed a large-scale molecular characterization
of living organisms, involving the generation and interpretation of data at an unprecedented …

Blood Proteomics-Based Detection of Upregulated Lipid Metabolism and Immune Dysfunction in an Elite Adventure Athlete Trekking Across Antarctica

D Nieman, A Groen, A Pugachev, A Simonson… - Current Developments …, 2020 - Elsevier
Objectives Proteomics when combined with psychological, nutrition, and performance
measures may serve as a useful monitoring system for immune dysfunction, training …

[引言][C] A SARS-CoV-2-Human protein-protein interaction map reveals drug targets and potential drug-repurposing. bioRxiv. 2020: 2020.03. 22.002386

DE Gordon, GM Jang, M Bouhaddou, J Xu, K Obernier… - Pediatric safety data were not …