The locus of evolution: evo devo and the genetics of adaptation
HE Hoekstra, JA Coyne - Evolution, 2007 - academic.oup.com
An important tenet of evolutionary developmental biology (“evo devo”) is that adaptive
mutations affecting morphology are more likely to occur in the cis-regulatory regions than in …
mutations affecting morphology are more likely to occur in the cis-regulatory regions than in …
Genetics, development and evolution of adaptive pigmentation in vertebrates
HE Hoekstra - Heredity, 2006 - nature.com
The study of pigmentation has played an important role in the intersection of evolution,
genetics, and developmental biology. Pigmentation's utility as a visible phenotypic marker …
genetics, and developmental biology. Pigmentation's utility as a visible phenotypic marker …
Strength and tempo of directional selection in the wild
Directional selection is a major force driving adaptation and evolutionary change. However,
the distribution, strength, and tempo of phenotypic selection acting on quantitative traits in …
the distribution, strength, and tempo of phenotypic selection acting on quantitative traits in …
The strength of phenotypic selection in natural populations
JG Kingsolver, HE Hoekstra… - The American …, 2001 - journals.uchicago.edu
How strong is phenotypic selection on quantitative traits in the wild? We reviewed the
literature from 1984 through 1997 for studies that estimated the strength of linear and …
literature from 1984 through 1997 for studies that estimated the strength of linear and …
A single amino acid mutation contributes to adaptive beach mouse color pattern
HE Hoekstra, RJ Hirschmann, RA Bundey, PA Insel… - Science, 2006 - science.org
Natural populations of beach mice exhibit a characteristic color pattern, relative to their
mainland conspecifics, driven by natural selection for crypsis. We identified a derived …
mainland conspecifics, driven by natural selection for crypsis. We identified a derived …
Double Digest RADseq: An Inexpensive Method for De Novo SNP Discovery and Genotyping in Model and Non-Model Species
The ability to efficiently and accurately determine genotypes is a keystone technology in
modern genetics, crucial to studies ranging from clinical diagnostics, to genotype-phenotype …
modern genetics, crucial to studies ranging from clinical diagnostics, to genotype-phenotype …
Does evolutionary theory need a rethink?
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Adaptive evolution of multiple traits through multiple mutations at a single gene
The identification of precise mutations is required for a complete understanding of the
underlying molecular and evolutionary mechanisms driving adaptive phenotypic change …
underlying molecular and evolutionary mechanisms driving adaptive phenotypic change …
On the origin and spread of an adaptive allele in deer mice
Adaptation is a central focus of biology, although it can be difficult to identify both the
strength and agent of selection and the underlying molecular mechanisms causing change …
strength and agent of selection and the underlying molecular mechanisms causing change …
Combining population genomics and quantitative genetics: finding the genes underlying ecologically important traits
JR Stinchcombe, HE Hoekstra - Heredity, 2008 - nature.com
A central challenge in evolutionary biology is to identify genes underlying ecologically
important traits and describe the fitness consequences of naturally occurring variation at …
important traits and describe the fitness consequences of naturally occurring variation at …