Differential network biology
Protein and genetic interaction maps can reveal the overall physical and functional
landscape of a biological system. To date, these interaction maps have typically been …
landscape of a biological system. To date, these interaction maps have typically been …
How many human proteoforms are there?
Despite decades of accumulated knowledge about proteins and their post-translational
modifications (PTMs), numerous questions remain regarding their molecular composition …
modifications (PTMs), numerous questions remain regarding their molecular composition …
Host cell factors in HIV replication: meta-analysis of genome-wide studies
We have analyzed host cell genes linked to HIV replication that were identified in nine
genome-wide studies, including three independent siRNA screens. Overlaps among the …
genome-wide studies, including three independent siRNA screens. Overlaps among the …
Global landscape of protein complexes in the yeast Saccharomyces cerevisiae
Identification of protein–protein interactions often provides insight into protein function, and
many cellular processes are performed by stable protein complexes. We used tandem …
many cellular processes are performed by stable protein complexes. We used tandem …
A SARS-CoV-2 protein interaction map reveals targets for drug repurposing
A newly described coronavirus named severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2), which is the causative agent of coronavirus disease 2019 (COVID-19), has …
(SARS-CoV-2), which is the causative agent of coronavirus disease 2019 (COVID-19), has …
Methylation of histone H3 by Set2 in Saccharomyces cerevisiae is linked to transcriptional elongation by RNA polymerase II
Set2 methylates Lys36 of histone H3. We show here that yeast Set2 copurifies with RNA
polymerase II (RNAPII). Chromatin immunoprecipitation analyses demonstrated that Set2 …
polymerase II (RNAPII). Chromatin immunoprecipitation analyses demonstrated that Set2 …
A Snf2 family ATPase complex required for recruitment of the histone H2A variant Htz1
Deletions of three yeast genes, SET2, CDC73, and DST1, involved in transcriptional
elongation and/or chromatin metabolism were used in conjunction with genetic array …
elongation and/or chromatin metabolism were used in conjunction with genetic array …
Functional dissection of protein complexes involved in yeast chromosome biology using a genetic interaction map
Defining the functional relationships between proteins is critical for understanding virtually
all aspects of cell biology. Large-scale identification of protein complexes has provided one …
all aspects of cell biology. Large-scale identification of protein complexes has provided one …
Exploration of the function and organization of the yeast early secretory pathway through an epistatic miniarray profile
M Schuldiner, SR Collins, NJ Thompson, V Denic… - Cell, 2005 - cell.com
We present a strategy for generating and analyzing comprehensive genetic-interaction
maps, termed E-MAPs (epistatic miniarray profiles), comprising quantitative measures of …
maps, termed E-MAPs (epistatic miniarray profiles), comprising quantitative measures of …
The Paf1 complex is required for histone H3 methylation by COMPASS and Dot1p: linking transcriptional elongation to histone methylation
NJ Krogan, J Dover, A Wood, J Schneider, J Heidt… - Molecular cell, 2003 - cell.com
Methylation of histone proteins is one of their many modifications that affect chromatin
structure and regulate gene expression. Methylation of histone H3 on lysines 4 and 79 …
structure and regulate gene expression. Methylation of histone H3 on lysines 4 and 79 …