Microglia development and function
Proper development and function of the mammalian central nervous system (CNS) depend
critically on the activity of parenchymal sentinels referred to as microglia. Although microglia …
critically on the activity of parenchymal sentinels referred to as microglia. Although microglia …
Inflammation and neuroprotection in traumatic brain injury
KN Corps, TL Roth, DB McGavern - JAMA neurology, 2015 - jamanetwork.com
Importance Traumatic brain injury (TBI) is a significant public health concern that affects
individuals in all demographics. With increasing interest in the medical and public …
individuals in all demographics. With increasing interest in the medical and public …
Annual research review: epigenetic mechanisms and environmental shaping of the brain during sensitive periods of development
TL Roth, J David Sweatt - Journal of Child Psychology and …, 2011 - Wiley Online Library
Experiences during early development profoundly affect development of the central nervous
system (CNS) to impart either risk for or resilience to later psychopathology. Work in the …
system (CNS) to impart either risk for or resilience to later psychopathology. Work in the …
Lasting epigenetic influence of early-life adversity on the BDNF gene
BACKGROUND: Childhood maltreatment and early trauma leave lasting imprints on neural
mechanisms of cognition and emotion. With a rat model of infant maltreatment by a …
mechanisms of cognition and emotion. With a rat model of infant maltreatment by a …
Reprogramming human T cell function and specificity with non-viral genome targeting
Decades of work have aimed to genetically reprogram T cells for therapeutic purposes,
using recombinant viral vectors, which do not target transgenes to specific genomic sites …
using recombinant viral vectors, which do not target transgenes to specific genomic sites …
Transcranial amelioration of inflammation and cell death after brain injury
Traumatic brain injury (TBI) is increasingly appreciated to be highly prevalent and
deleterious to neurological function,. At present, no effective treatment options are available …
deleterious to neurological function,. At present, no effective treatment options are available …
A SARS-CoV-2 protein interaction map reveals targets for drug repurposing
A newly described coronavirus named severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2), which is the causative agent of coronavirus disease 2019 (COVID-19), has …
(SARS-CoV-2), which is the causative agent of coronavirus disease 2019 (COVID-19), has …
Evidence that DNA (cytosine-5) methyltransferase regulates synaptic plasticity in the hippocampus
DNA (cytosine-5) methylation represents one of the most widely used mechanisms of
enduring cellular memory. Stable patterns of DNA methylation are established during …
enduring cellular memory. Stable patterns of DNA methylation are established during …
Epigenetic modification of hippocampal Bdnf DNA in adult rats in an animal model of post-traumatic stress disorder
Epigenetic alterations of the brain-derived neurotrophic factor (Bdnf) gene have been linked
with memory, stress, and neuropsychiatric disorders. Here we examined whether there was …
with memory, stress, and neuropsychiatric disorders. Here we examined whether there was …
Epigenetic regulation of BDNF gene transcription in the consolidation of fear memory
Long-term memory formation requires selective changes in gene expression. Here, we
determined the contribution of chromatin remodeling to learning-induced changes in brain …
determined the contribution of chromatin remodeling to learning-induced changes in brain …