Macrophages in the gastrointestinal mucosa represent the largest pool of tissue
macrophages in the body. In order to maintain mucosal homeostasis, resident intestinal …

Aims: Bisulfite sequence analysis of individual CpG sites within genomic DNA is a powerful
approach for methylation analysis in the genome. The major limitation of bisulfite-based …

We have developed a flexible, accurate and highly multiplexed SNP genotyping assay for
high-throughput genetic analysis of large populations on a bead array platform. The novel …

We describe the landscape of somatic genomic alterations based on multidimensional and
comprehensive characterization of more than 500 glioblastoma tumors (GBMs). We identify …

The genome of the japonica subspecies of rice, an important cereal and model monocot,
was sequenced and assembled by whole-genome shotgun sequencing. The assembled …

Immune checkpoint inhibitor (ICI) treatments benefit some patients with metastatic cancers,
but predictive biomarkers are needed. Findings in selected cancer types suggest that tumor …

We conducted comprehensive integrative molecular analyses of the complete set of tumors
in The Cancer Genome Atlas (TCGA), consisting of approximately 10,000 specimens and …

Liver cancer has the second highest worldwide cancer mortality rate and has limited
therapeutic options. We analyzed 363 hepatocellular carcinoma (HCC) cases by whole …

Urine provides an alternative to blood plasma as a potential source of disease biomarkers.
One urinary biomarker already exploited in clinical studies is aquaporin-2. However, it …

The Polycomb Group Protein EZH2 is a transcriptional repressor involved in controlling
cellular memory and has been linked to aggressive prostate cancer. Here we investigate the …