A SARS-CoV-2 protein interaction map reveals targets for drug repurposing
A newly described coronavirus named severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2), which is the causative agent of coronavirus disease 2019 (COVID-19), has …
(SARS-CoV-2), which is the causative agent of coronavirus disease 2019 (COVID-19), has …
Activation of the PD-1 pathway contributes to immune escape in EGFR-driven lung tumors
EA Akbay, S Koyama, J Carretero, A Altabef… - Cancer discovery, 2013 - AACR
The success in lung cancer therapy with programmed death (PD)-1 blockade suggests that
immune escape mechanisms contribute to lung tumor pathogenesis. We identified a …
immune escape mechanisms contribute to lung tumor pathogenesis. We identified a …
[HTML][HTML] The global phosphorylation landscape of SARS-CoV-2 infection
M Bouhaddou, D Memon, B Meyer, KM White… - Cell, 2020 - cell.com
The causative agent of the coronavirus disease 2019 (COVID-19) pandemic, severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2), has infected millions and killed …
respiratory syndrome coronavirus 2 (SARS-CoV-2), has infected millions and killed …
Evolution of enhanced innate immune evasion by SARS-CoV-2
LG Thorne, M Bouhaddou, AK Reuschl… - Nature, 2022 - nature.com
The emergence of SARS-CoV-2 variants of concern suggests viral adaptation to enhance
human-to-human transmission,. Although much effort has focused on the characterization of …
human-to-human transmission,. Although much effort has focused on the characterization of …
Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms
INTRODUCTION The emergence of three lethal coronaviruses in< 20 years and the urgency
of the COVID-19 pandemic have prompted efforts to develop new therapeutic strategies …
of the COVID-19 pandemic have prompted efforts to develop new therapeutic strategies …
STK11/LKB1 deficiency promotes neutrophil recruitment and proinflammatory cytokine production to suppress T-cell activity in the lung tumor microenvironment
STK11/LKB1 is among the most commonly inactivated tumor suppressors in non–small cell
lung cancer (NSCLC), especially in tumors harboring KRAS mutations. Many oncogenes …
lung cancer (NSCLC), especially in tumors harboring KRAS mutations. Many oncogenes …
The functional landscape of the human phosphoproteome
Protein phosphorylation is a key post-translational modification regulating protein function in
almost all cellular processes. Although tens of thousands of phosphorylation sites have …
almost all cellular processes. Although tens of thousands of phosphorylation sites have …
Intratumoral Heterogeneity in EGFR-Mutant NSCLC Results in Divergent Resistance Mechanisms in Response to EGFR Tyrosine Kinase Inhibition
M Soucheray, M Capelletti, I Pulido, Y Kuang… - Cancer research, 2015 - AACR
Non–small cell lung cancers (NSCLC) that have developed resistance to EGF receptor
(EGFR) tyrosine kinase inhibitor (TKI), including gefitinib and erlotinib, are clinically linked to …
(EGFR) tyrosine kinase inhibitor (TKI), including gefitinib and erlotinib, are clinically linked to …
A protein interaction landscape of breast cancer
INTRODUCTION Advances in DNA sequencing technology have enabled the widespread
analysis of breast tumor genomes, creating a catalog of genetic mutations that may initiate or …
analysis of breast tumor genomes, creating a catalog of genetic mutations that may initiate or …
Impact of SARS-CoV-2 ORF6 and its variant polymorphisms on host responses and viral pathogenesis
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) encodes several proteins
that inhibit host interferon responses. Among these, ORF6 antagonizes interferon signaling …
that inhibit host interferon responses. Among these, ORF6 antagonizes interferon signaling …