In the genome of a germ-line cell, the genetic information for an immunoglobulin polypeptide
chain is contained in multiple gene segments scattered along a chromosome. During the …

BACKGROUND The idea that memory is stored as enduring changes in the brain dates
back at least to the time of Plato and Aristotle (circa 350 BCE), but its scientific articulation …

Before TCR rearrangements, T cell progenitors are committed not only to the ap and yJ T
cell lineage but also to various subsets of both lineages. In the mouse, distinct yJ T cell …

Episodic memories initially require rapid synaptic plasticity within the hippocampus for their
formation and are gradually consolidated in neocortical networks for permanent storage …

Summary The V (D) J recombination activation gene RAG-1 was isolated on the basis of its
ability to activate V (D) J recombination on an artificial substrate in fibroblasts. This property …

We have studied the DNA sequences required for high level expression of a cloned heavy
chain immunoglobulin gene stably introduced into mouse myeloma cells by DNA …

Adult-born granule cells (GCs), a minor population of cells in the hippocampal dentate
gyrus, are highly active during the first few weeks after functional integration into the …

A high-molecular-weight DNA from Balb/c mouse early embryo or from MOPC 321
plasmacytoma (a k-chain producer) was digested to completion with Bacillus …

Using a pCRI plasmid containing an enzymatically synthesized, full-length DNA transcript of
immunoglobulin A chain mRNA as the hybridization probe in the Southern gel blotting …

The medial temporal lobe, including the hippocampus, has been implicated in social
memory. However, it remains unknown which parts of these brain regions and their circuits …