A SARS-CoV-2 protein interaction map reveals targets for drug repurposing
A newly described coronavirus named severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2), which is the causative agent of coronavirus disease 2019 (COVID-19), has …
(SARS-CoV-2), which is the causative agent of coronavirus disease 2019 (COVID-19), has …
Ligand binding remodels protein side-chain conformational heterogeneity
SA Wankowicz, SH de Oliveira, DW Hogan… - Elife, 2022 - elifesciences.org
While protein conformational heterogeneity plays an important role in many aspects of
biological function, including ligand binding, its impact has been difficult to quantify …
biological function, including ligand binding, its impact has been difficult to quantify …
Structural alterations driving castration-resistant prostate cancer revealed by linked-read genome sequencing
Nearly all prostate cancer deaths are from metastatic castration-resistant prostate cancer
(mCRPC), but there have been few whole-genome sequencing (WGS) studies of this …
(mCRPC), but there have been few whole-genome sequencing (WGS) studies of this …
Cryo-EM model validation recommendations based on outcomes of the 2019 EMDataResource challenge
This paper describes outcomes of the 2019 Cryo-EM Model Challenge. The goals were to
(1) assess the quality of models that can be produced from cryogenic electron microscopy …
(1) assess the quality of models that can be produced from cryogenic electron microscopy …
Genomic predictors of good outcome, recurrence, or progression in high-grade t1 non–muscle-invasive bladder cancer
Abstract High-grade T1 (HGT1) bladder cancer is the highest risk subtype of non–muscle-
invasive bladder cancer with unpredictable outcome and poorly understood risk factors …
invasive bladder cancer with unpredictable outcome and poorly understood risk factors …
Integrative molecular characterization of resistance to neoadjuvant chemoradiation in rectal cancer
SC Kamran, JK Lennerz, CA Margolis, D Liu… - Clinical Cancer …, 2019 - AACR
Purpose: Molecular properties associated with complete response or acquired resistance to
concurrent chemotherapy and radiotherapy (CRT) are incompletely characterized …
concurrent chemotherapy and radiotherapy (CRT) are incompletely characterized …
Molecular features of exceptional response to neoadjuvant anti-androgen therapy in high-risk localized prostate cancer
AK Tewari, ATM Cheung, J Crowdis, JR Conway… - Cell Reports, 2021 - cell.com
High-risk localized prostate cancer (HRLPC) is associated with a substantial risk of
recurrence and disease mortality. Recent clinical trials have shown that intensifying anti …
recurrence and disease mortality. Recent clinical trials have shown that intensifying anti …
qFit 3: Protein and ligand multiconformer modeling for X‐ray crystallographic and single‐particle cryo‐EM density maps
BT Riley, SA Wankowicz, SHP de Oliveira… - Protein …, 2021 - Wiley Online Library
New X‐ray crystallography and cryo‐electron microscopy (cryo‐EM) approaches yield vast
amounts of structural data from dynamic proteins and their complexes. Modeling the full …
amounts of structural data from dynamic proteins and their complexes. Modeling the full …
[HTML][HTML] Uncovering protein ensembles: automated multiconformer model building for X-ray crystallography and cryo-EM
In their folded state, biomolecules exchange between multiple conformational states that are
crucial for their function. Traditional structural biology methods, such as X-ray …
crucial for their function. Traditional structural biology methods, such as X-ray …
Racial disparity in quality of care and overall survival among black vs. white patients with muscle-invasive bladder cancer treated with radical cystectomy: A national …
P Gild, SA Wankowicz, A Sood… - … Oncology: Seminars and …, 2018 - Elsevier
Objectives To examine the impact of race on quality of care and overall survival (OS) among
patients with muscle invasive bladder cancer (MIBC) treated with radical cystectomy (RC) in …
patients with muscle invasive bladder cancer (MIBC) treated with radical cystectomy (RC) in …