A newly described coronavirus named severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2), which is the causative agent of coronavirus disease 2019 (COVID-19), has …

While protein conformational heterogeneity plays an important role in many aspects of
biological function, including ligand binding, its impact has been difficult to quantify …

Nearly all prostate cancer deaths are from metastatic castration-resistant prostate cancer
(mCRPC), but there have been few whole-genome sequencing (WGS) studies of this …

This paper describes outcomes of the 2019 Cryo-EM Model Challenge. The goals were to
(1) assess the quality of models that can be produced from cryogenic electron microscopy …

Abstract High-grade T1 (HGT1) bladder cancer is the highest risk subtype of non–muscle-
invasive bladder cancer with unpredictable outcome and poorly understood risk factors …

Purpose: Molecular properties associated with complete response or acquired resistance to
concurrent chemotherapy and radiotherapy (CRT) are incompletely characterized …

High-risk localized prostate cancer (HRLPC) is associated with a substantial risk of
recurrence and disease mortality. Recent clinical trials have shown that intensifying anti …

New X‐ray crystallography and cryo‐electron microscopy (cryo‐EM) approaches yield vast
amounts of structural data from dynamic proteins and their complexes. Modeling the full …

In their folded state, biomolecules exchange between multiple conformational states that are
crucial for their function. Traditional structural biology methods, such as X-ray …

Objectives To examine the impact of race on quality of care and overall survival (OS) among
patients with muscle invasive bladder cancer (MIBC) treated with radical cystectomy (RC) in …