A SARS-CoV-2 protein interaction map reveals targets for drug repurposing
A newly described coronavirus named severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2), which is the causative agent of coronavirus disease 2019 (COVID-19), has …
(SARS-CoV-2), which is the causative agent of coronavirus disease 2019 (COVID-19), has …
Global signal peptide profiling reveals principles of selective Sec61 inhibition
NA Wenzell, BB Tuch, DL McMinn, MJ Lyons… - Nature Chemical …, 2024 - nature.com
Cotransins target the Sec61 translocon and inhibit the biogenesis of an undefined subset of
secretory and membrane proteins. Remarkably, cotransin inhibition depends on the unique …
secretory and membrane proteins. Remarkably, cotransin inhibition depends on the unique …
Signal peptide mimicry primes Sec61 for client-selective inhibition
Preventing the biogenesis of disease-relevant proteins is an attractive therapeutic strategy,
but attempts to target essential protein biogenesis factors have been hampered by …
but attempts to target essential protein biogenesis factors have been hampered by …
Electronic and Steric Control of n→ π* Interactions: Stabilization of the α‐Helix Conformation without a Hydrogen Bond
The preferred conformations of peptides and proteins are dependent on local interactions
that bias the conformational ensemble. The n→ π* interaction between consecutive …
that bias the conformational ensemble. The n→ π* interaction between consecutive …
The Distinct Conformational Landscapes of 4S‐Substituted Prolines That Promote an endo Ring Pucker
NV Costantini, HK Ganguly, MI Martin… - … A European Journal, 2019 - Wiley Online Library
Substitution on proline directly impacts protein main chain conformational preferences. The
structural effects of N‐acyl substitution and of 4‐substitution were examined by NMR …
structural effects of N‐acyl substitution and of 4‐substitution were examined by NMR …
UNDERSTANDING A FUNDAMENTAL FORCE IN PROTEIN FOLDING: TUNING THE n ‐‐> > π* INTERACTION VIA DESIGNED PEPTIDES
NA Wenzell, HK Ganguly, AK Pandey… - The FASEB …, 2016 - Wiley Online Library
An n‐‐> π* interaction is a local interaction that orders two consecutive residues by
delocalizing the lone pair of electrons from oxygen of the donor carbonyl to the antibonding …
delocalizing the lone pair of electrons from oxygen of the donor carbonyl to the antibonding …