Cell signalling and endocytic membrane trafficking have traditionally been viewed as distinct
processes. Although our present understanding is incomplete and there are still great …

Binding of hormones, growth factors and other cell modulators to cell-surface receptors
triggers a complex array of signal-transduction events. The activation of many receptors also …

The concept of intrinsic efficacy has been enshrined in pharmacology for half of a century,
yet recent data have revealed that many ligands can differentially activate signaling …

A newly described coronavirus named severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2), which is the causative agent of coronavirus disease 2019 (COVID-19), has …

A long-held tenet of molecular pharmacology is that canonical signal transduction mediated
by G-protein-coupled receptor (GPCR) coupling to heterotrimeric G proteins is confined to …

Activity-dependent modulation of synaptic efficacy in the brain contributes to neural circuit
development and experience-dependent plasticity. Although glia are affected by activity and …

Agonist-regulated redistribution of human beta 2-adrenergic receptors was examined in 293
cells. A specific antiserum recognizing the carboxyl-terminal hydrophilic domain of the …

A fundamental question in cell biology is how membrane proteins are sorted in the endocytic
pathway. The sorting of internalized β2-adrenergic receptors between recycling endosomes …

The heterogeneity of neural gene expression and the spatially limited expression of many
low-abundance messenger RNAs in the brain has made cloning and analysis of such …

Clathrin-coated pits (CCPs) are generally considered a uniform population of endocytic
machines containing mixed constitutive and regulated membrane cargo. Contrary to this …