Chronic Obstructive Pulmonary Disease (COPD) is one of those progressive diseases that deteriorate lung functions. When patients cannot breathe, nothing else in their lives matters. Moreover, a lack of relevant and updated information about the causes and consequences of the disease can exacerbate the problems of health literacy, information accessibility, and medical adherence. The objective of this study is to design an innovative mobile-based assistive technology through the lens of design science research (DSR). This IT artifact includes three integrative modules that have not been introduced before in the literature: education, risk reduction, and monitoring. The evaluation study uses mixed methods to thoroughly understand how the assistive mobile-based technology can influence patients’ behavioral intention to change their lifestyle. The contribution of this study is the innovative IT artifact that functions as a complete solution for patients and their caregivers. We also discuss few design principles that capture knowledge about designing mobile-based technology and demonstrate the impact of the use of this mobile-based artifact by patients with COPD and their caregivers.