Thrombosis and thrombocytopenia after ChAdOx1 nCoV-19 vaccination
NH Schultz, IH Sørvoll, AE Michelsen… - New England journal …, 2021 - Mass Medical Soc
We report findings in five patients who presented with venous thrombosis and
thrombocytopenia 7 to 10 days after receiving the first dose of the ChAdOx1 nCoV-19
adenoviral vector vaccine against coronavirus disease 2019 (Covid-19). The patients were
health care workers who were 32 to 54 years of age. All the patients had high levels of
antibodies to platelet factor 4–polyanion complexes; however, they had had no previous
exposure to heparin. Because the five cases occurred in a population of more than 130,000 …
thrombocytopenia 7 to 10 days after receiving the first dose of the ChAdOx1 nCoV-19
adenoviral vector vaccine against coronavirus disease 2019 (Covid-19). The patients were
health care workers who were 32 to 54 years of age. All the patients had high levels of
antibodies to platelet factor 4–polyanion complexes; however, they had had no previous
exposure to heparin. Because the five cases occurred in a population of more than 130,000 …
Thrombotic thrombocytopenia after ChAdOx1 nCov-19 vaccination
A Greinacher, T Thiele, TE Warkentin… - … England Journal of …, 2021 - Mass Medical Soc
Background Several cases of unusual thrombotic events and thrombocytopenia have
developed after vaccination with the recombinant adenoviral vector encoding the spike
protein antigen of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-
2)(ChAdOx1 nCov-19, AstraZeneca). More data were needed on the pathogenesis of this
unusual clotting disorder. Methods We assessed the clinical and laboratory features of 11
patients in Germany and Austria in whom thrombosis or thrombocytopenia had developed …
developed after vaccination with the recombinant adenoviral vector encoding the spike
protein antigen of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-
2)(ChAdOx1 nCov-19, AstraZeneca). More data were needed on the pathogenesis of this
unusual clotting disorder. Methods We assessed the clinical and laboratory features of 11
patients in Germany and Austria in whom thrombosis or thrombocytopenia had developed …