[HTML][HTML] Vaccine-induced massive pulmonary embolism and thrombocytopenia following a single dose of Janssen Ad26. COV2. S vaccination
R Curcio, V Gandolfo, R Alcidi, L Giacomino… - International Journal of …, 2022 - Elsevier
R Curcio, V Gandolfo, R Alcidi, L Giacomino, T Campanella, G Casarola, R Rossi, L Chiatti…
International Journal of Infectious Diseases, 2022•ElsevierVaccine-induced immune thrombotic thrombocytopenia (VITT) has emerged as a rare side
effect of adenoviral vector-based vaccines against coronavirus disease 2019 (COVID-19),
and is most frequently reported after use of the Vaxzevria (AstraZeneca) vaccine. This report
describes a case of severe thrombocytopenia associated with massive pulmonary embolism
and portal vein thrombosis occurring 13 days after the administration of the single-dose
adenoviral vector-based vaccine Ad26. COV2. S (Janssen Vaccines). Based on early …
effect of adenoviral vector-based vaccines against coronavirus disease 2019 (COVID-19),
and is most frequently reported after use of the Vaxzevria (AstraZeneca) vaccine. This report
describes a case of severe thrombocytopenia associated with massive pulmonary embolism
and portal vein thrombosis occurring 13 days after the administration of the single-dose
adenoviral vector-based vaccine Ad26. COV2. S (Janssen Vaccines). Based on early …
Abstract
Vaccine-induced immune thrombotic thrombocytopenia (VITT) has emerged as a rare side effect of adenoviral vector-based vaccines against coronavirus disease 2019 (COVID-19), and is most frequently reported after use of the Vaxzevria (AstraZeneca) vaccine. This report describes a case of severe thrombocytopenia associated with massive pulmonary embolism and portal vein thrombosis occurring 13 days after the administration of the single-dose adenoviral vector-based vaccine Ad26.COV2.S (Janssen Vaccines). Based on early clinical suspicion, the patient quickly received treatment with corticosteroids and intravenous immunoglobulin, followed by a rapid increase in platelet count that allowed timely administration of full-dose anticoagulation. Treatment with intravenous immunoglobulin, however, could mask the ability of anti-platelet factor 4-heparin antibodies to bind and activate platelets in the presence of heparin, leading to false-negative results on the immunoassay functional test. Therefore, if VITT is suspected, blood samples for diagnostic confirmation should be collected prior to any treatment to improve diagnostic performance.
Elsevier