Sex differences in renal function: Participation of gonadal hormones and prolactin
A Franco-Acevedo, R Echavarria, Z Melo - Endocrines, 2021 - mdpi.com
A Franco-Acevedo, R Echavarria, Z Melo
Endocrines, 2021•mdpi.comKidney pathophysiology is influenced by gender. Evidence suggests that kidney damage is
more severe in males than in females and that sexual hormones contribute to this. Elevated
prolactin concentration is common in renal impairment patients and is associated with an
unfavorable prognosis. However, PRL is involved in the osmoregulatory process and
promotes endothelial proliferation, dilatation, and permeability in blood vessels. Several
proteinases cleavage its structure, forming vasoinhibins. These fragments have antagonistic …
more severe in males than in females and that sexual hormones contribute to this. Elevated
prolactin concentration is common in renal impairment patients and is associated with an
unfavorable prognosis. However, PRL is involved in the osmoregulatory process and
promotes endothelial proliferation, dilatation, and permeability in blood vessels. Several
proteinases cleavage its structure, forming vasoinhibins. These fragments have antagonistic …
Kidney pathophysiology is influenced by gender. Evidence suggests that kidney damage is more severe in males than in females and that sexual hormones contribute to this. Elevated prolactin concentration is common in renal impairment patients and is associated with an unfavorable prognosis. However, PRL is involved in the osmoregulatory process and promotes endothelial proliferation, dilatation, and permeability in blood vessels. Several proteinases cleavage its structure, forming vasoinhibins. These fragments have antagonistic PRL effects on endothelium and might be associated with renal endothelial dysfunction, but its role in the kidneys has not been enough investigated. Therefore, the purpose of this review is to describe the influence of sexual dimorphism and gonadal hormones on kidney damage, emphasizing the role of the hormone prolactin and its cleavage products, the vasoinhibins.
![](/scholar/images/qa_favicons/mdpi.com.png)