It is clear that reproductive aging plays a critical role in overall population health and
longevity. The effects of ovarian aging on overall health are largely due to the progressive,
irreversible loss of follicles and oocytes, which results in declining feedback from the somatic
cells of the aging ovary, changes in endocrine hormones, and ultimately, menopause.
Menopause, the culmination of the ovarian aging process, represents a major hormonal,
psychological, and physiological event and confers increased risk for comorbidities and …