Acute kidney injury in pregnancies complicated with preeclampsia or HELLP syndrome
J Szczepanski, A Griffin, S Novotny, K Wallace - Frontiers in medicine, 2020 - frontiersin.org
J Szczepanski, A Griffin, S Novotny, K Wallace
Frontiers in medicine, 2020•frontiersin.orgAcute kidney injury that occurs during pregnancy or in the post-partum period (PR-AKI) is a
serious obstetric complication with risk of significant associated maternal and fetal morbidity
and mortality. Recent data indicates that the incidence of PR-AKI is increasing, although
accurate calculation is limited by the lack of a uniform diagnostic criteria that is validated in
pregnancy. Hypertensive and thrombotic microangiopathic disorders of pregnancy have
been identified as major contributors to the burden of PR-AKI. As is now accepted regarding …
serious obstetric complication with risk of significant associated maternal and fetal morbidity
and mortality. Recent data indicates that the incidence of PR-AKI is increasing, although
accurate calculation is limited by the lack of a uniform diagnostic criteria that is validated in
pregnancy. Hypertensive and thrombotic microangiopathic disorders of pregnancy have
been identified as major contributors to the burden of PR-AKI. As is now accepted regarding …
Acute kidney injury that occurs during pregnancy or in the post-partum period (PR-AKI) is a serious obstetric complication with risk of significant associated maternal and fetal morbidity and mortality. Recent data indicates that the incidence of PR-AKI is increasing, although accurate calculation is limited by the lack of a uniform diagnostic criteria that is validated in pregnancy. Hypertensive and thrombotic microangiopathic disorders of pregnancy have been identified as major contributors to the burden of PR-AKI. As is now accepted regarding preeclampsia, HELLP syndrome and atypical hemolytic uremic syndrome, it is believed that PR-AKI may have long-term renal, cardiovascular and neurocognitive consequences that persist beyond the post-partum period. Further research regarding PR-AKI could be advanced by the development of a pregnancy-specific validated definition and classification system; and the establishment of refined animal models that would allow researchers to further elucidate the mechanisms and sequelae of the disorder.
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