New knowledge about male–female differences in pathophysiology, diagnosis, and
treatment is shifting the practice of medicine from a one-size-fits all approach to a more
individualized process that considers sex-specific interventions at the point of care. In this
article, we review how clinical practice guideline committees can incorporate a structured
framework to determine whether sex-specific assessments of the quality of the evidence or
the particular recommendations should be made. The process can be operationalized by …