Iron deficiency anemia: guidelines from the American Gastroenterological Association

K Sonoda - American Family Physician, 2021 - aafp.org
American Family Physician, 2021aafp.org
Diagnosing Iron Deficiency The AGA defines anemia as a hemoglobin level of less than 13
g per dL (130 g per L) in men and less than 12 g per dL (120 g per L) in patients who are not
pregnant. Serum ferritin testing is commonly used to diagnose iron deficiency in patients
with anemia. Based on a systematic review, the AGA recommends using a ferritin threshold
value of less than 45 ng per mL (45 mcg per L) for diagnosing iron deficiency in patients with
anemia. This threshold has 85% sensitivity and 92% specificity for iron deficiency. Without …
Diagnosing Iron Deficiency The AGA defines anemia as a hemoglobin level of less than 13 g per dL (130 g per L) in men and less than 12 g per dL (120 g per L) in patients who are not pregnant. Serum ferritin testing is commonly used to diagnose iron deficiency in patients with anemia. Based on a systematic review, the AGA recommends using a ferritin threshold value of less than 45 ng per mL (45 mcg per L) for diagnosing iron deficiency in patients with anemia.
This threshold has 85% sensitivity and 92% specificity for iron deficiency. Without anemia, the ferritin threshold for iron deficiency is uncertain. Ferritin testing is less accurate in patients with chronic inflammatory conditions or chronic kidney disease, and additional tests including serum iron, transferrin saturation, soluble transferrin receptor, and C-reactive protein can help diagnose iron deficiency.
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