Pharmetheus

We are delighted to welcome Lourdes Cucurull-Sanchez as the Scientific Lead for QSP! 🌟 Lourdes will further develop this growing area, demonstrated to be of great help to tackle drug development challenges, ultimately benefiting patients. She brings more than twenty years of experience in drug development, using quantitative approaches in companies like Pfizer and GSK. She’s also the current chair of the QSP Special Interest Group (SIG) at ISoP (International Society of Pharmacometrics). She is based in the UK and will be working from her home office. Read more: https://lnkd.in/gHG8-UmU #career #pharmacometrics #lifesciences #pharmaceutical #QSP

We're wrapping up our time at PharmSci360 in beautiful Salt Lake City! The event was filled with exciting talks and conversations, and we truly enjoyed connecting with you at our booth. Sharing our insights through Ass. Prof. Erik Sjögren's rapid-fire talk was also a pleasure. Thank you to everyone who made this event valuable. We're excited to continue these discussions and build on the connections we've made! #PharmSci360 #Pharmacometrics #Networking #Lifescience

Sign up for a digital student speed advising session, or meet our experts in person at ACoP! We offer one hour of free, personalized, high-quality advice tailored to your unique challenges within pharmacometrics and PBPK. The sessions are offered between 11-22 November, 2024. Read more and sign up here: https://lnkd.in/deCM2YW3 #Pharmacometrics #ProfessionalDevelopment #students #career #ACoP2024

We are very happy to have Oskar Clewe and Merel Hazewindus, PhD on board at Pharmetheus as QC and Medical Writers! 🤩 Oskar’s experience includes developing strategies for and carrying out pharmacometric and MIDD approaches in both early and late-stage clinical drug development. Merel’s experience includes medical writing for clinical trial development and drug marketing authorization. Oskar is based in Sweden and Merel in the Netherlands, both of them will be working from their home offices. Link to Oskar’s bio: https://lnkd.in/dMzW4zDi Link to Merel’s bio: https://lnkd.in/du_mptHb #career #pharmacometrics #lifesciences #pharmaceutical

Current treatments in infantile colic are insufficient, with inadequate efficacy or intolerable side-effects. Nepadutant, a tachykinin NK2 receptor antagonist, was considered a promising candidate through its mechanism of action and for its potential to be dosed orally in infants. In a new publication by Siv Jönsson, Salim Bouchene, Paolo Mazzei, Elisa Borella, Chiara Piana, Alessia Tagliavini, Sibylle Koletzko, Katharina Werkstetter, angela capriati, Andrea Pellacani, Mats O. Karlsson and Niclas Jonsson, the pharmacokinetics and exposure–response (duration of crying and fussing) following treatment with nepadutant were described in infants (4-20 weeks) with colic. The continuous response variable, duration of crying and fussing in minutes within 2 h interval, was assembled based on records from "Baby's day Diary©". It was found that nepadutant was absorbed in infants following oral administration but exhibiting large inter-subject variability. The circadian rhythm and the duration of crying and fussing was characterized with the lowest and maximum duration occurring at 4 a.m. and 9 p.m., respectively. The placebo effect was time dependent and a statistically significant (P < .01) effect of nepadutant dose was established. This analysis provides an illustrative example involving an interesting response variable for which the baseline, placebo and drug treatment responses were disentangled and described in a model that can be used for simulations of alternative dose regimens. Link to publication: https://lnkd.in/dcRsk9cV #pharmacometrics #drugdevelopment #specialpopulations #lifesciences

Congratulations to this International Society of Pharmacometrics leadership award, Mats O. Karlsson! You are a true inspiration, and a great leader - not only for us at Pharmetheus and Uppsala University, but for the global pharmacometrics community. 🎇 #pharmacometrics #drugdevelopment #lifesciences #pharmaceutical #ACoP2024

We warmly welcome two new employees to further strengthen our Compliance team, Lena Lindeberg and Harriet Mellenius, PhD. ✨   Lena’s experience includes ICH-GCP and other Clinical Trial Regulations, Clinical & Regulatory Project Management, Strategies, Quality Assurance & Vendor Management as well as Leadership and coaching. Harriet’s experience as a quality consultant in the Life Sciences has involved managing quality associated documentation, and coordination, of quality associated activities in large and small businesses. Both Lena and Harriet are based in Sweden and will be working from our Uppsala office. Link to Lena’s bio: https://lnkd.in/dWMP9Pca Link to Harriet’s bio: https://lnkd.in/dmn5PXfS #career #pharmacometrics #lifesciences #pharmaceutical

We are looking forward to meeting the great community at GMP next week! Our contributions to the programme: 📍Johanna Eriksson, oral presentation: "Optimizing formulations for treatment of cryptococcal meningoencephalitis in sub-saharan HIV patients: insights from PBPK modeling", 📍Gianluca Selvaggio oral presentation: "A quantative systems pharmacology framework of immunogenicity to propose mitigation strategies after subcutaneous administration", and 📍Quentin Leirens, a poster: "A workflow for comparing drug candidates based on Probability of Pharmacological Success (POPS)", and also, 📍Fanny Gallais, chairing a session: "Special populations in drug development and clinical practice". See you there! #drugdevelopment #lifesciences #pharmaceutical #biosimulation

🌟 Excellent presentations by Eva Wehrhahn, Oscar Silfvergren, Viktor Skantze, Daniel Röshammar, Marcus Baaz and Martin Bergstrand today at the SUP fall meeting (Stockholm-Uppsala Pharmacometrics). Interesting questions from an engaged audience, and great to meet the pharmacometrics community. See you in the spring at Apotekarsocieteten. Thanks to the SUP committee for letting us host the meeting at our office, and to Siv Jönsson for being such an excellent host and facilitator. #pharmacometrics #pharmaceutical #lifescience #drugdevelopment

We're thrilled to be attending AAPS 2024 PharmSci 360! Make sure to catch Assoc. Prof. Erik Sjögren's rapid-fire talk on "Informing Subcutaneous Drug Development: Predictions of Absorption, Bioavailability, and Immunogenicity" on Tuesday, October 22, 3:30 PM to 3:45 PM, and stop by booth #2824 to learn about our services and solutions. We are looking forward to meeting you at American Association of Pharmaceutical Scientists (AAPS) | @aapscomms 2024 PharmSci 360, and if you want to make sure we meet up, don’t hesitate to already now schedule a meeting: https://lnkd.in/dU7Pgisx #PharmSci360 #pharmaceutical #pharmacometrics #Drugdevelopment