SciLifeLab

More precise and effective treatment of patients with rare diseases could now be developed, after a team of Swedish clinicians and researchers has discovered an unexpected complexity in chromosomal abnormalities. ↓ This has been done by using #LongReadSequencing, a new technique that allows DNA to be analyzed in much greater detail than before. “There is an extremely rapid development of long-read sequencing technologies, which means that more and more individuals will be analyzed with higher precision and at a lower cost” says the study’s first author Adam Ameur, a bioinformatician at Uppsala University and SciLifeLab National Genomics Infrastructure - NGI. The study was led by researchers at SciLifeLab, Karolinska Institutet/Karolinska University Hospital and Uppsala University, and involved clinicians and researchers from across Sweden. “The strength of the project lies in the broad collaboration between researchers and clinicians from all Genomic Medicine Centers and national research platforms, Clinical Genomics and National Genomics Infrastructure, at SciLifeLab. We were able to test this ground-breaking technique on clinical samples” says the study’s last author Lars Feuk, Professor at Uppsala University and Co-director of the SciLifeLab National Genomics Infrastructure. Learn more in the Genomic Medicine Sweden article here: https://lnkd.in/dFTtKS24 SciLifeLab Clinical Genomics

The SciLifeLab unit Swedish Metabolomics Centre (SMC) recently hosted a workshop for young scientists eager to delve into the world of metabolomics. The workshop focused on the rapidly evolving role of data analysis in interpreting complex datasets, which are crucial for advancing metabolomics research, and was organized in collaboration with the Institute for Molecular Medicine Finland (FIMM), the University of Helsinki and the The Laboratory for Molecular Infection Medicine Sweden, MIMS. The Swedish Metabolomics Centre is a collaboration between the SLU - Swedish University of Agricultural Sciences and Umeå University, as well as a SciLifeLab unit. Read more about the workshop and metabolomics research ↓ https://lnkd.in/dFFXEqCb

Join us for the official launch of the Swedish Reference Genome Portal – a free service that reduces barriers to the visualization and interpretation of genome data studied in Sweden, while facilitating collaboration, showcasing researchers’ work, and promoting Open Science and FAIR data sharing. The Swedish Reference Genome Portal is a web platform for showcasing, aggregating, and visualising non-human eukaryotic genome assemblies and genome annotations. Learn more and register for the event ↓ https://lnkd.in/dgwjFTD3 This service is supported by SciLifeLab and the Knut och Alice Wallenbergs Stiftelse through the DDLS program, as well as by the Swedish Foundation for Strategic Research (Stiftelsen för strategisk forskning, SSF).

SciLifeLab researchers Kutter Claudia and Carlos Gallardo Dodd (Karolinska Institutet) have written a new review covering the critical role of RNAs and RNA-binding proteins (RBPs) in maintaining cellular health! Read more in the article below ↓

To strengthen infrastructure career development, and to ensure the continuation of state-of-the-art technological services within life science research, SciLifeLab engages in ARISE2, the European career accelerator for research infrastructure scientists! Read more via the link below! https://lnkd.in/dHawYbGZ

Funding opportunity! InfraLife has opened a call to promote infrastructure use and collaboration within Life Science. If you are interested in using more than SciLifeLab, MAX IV Laboratory or European Spallation Source ERIC/DEMAX in the same project, be sure to submit your application before November 28th. Full details about the call and application process can be found here: https://lnkd.in/dWNRZ6Gj

Spread the word: RNA is back on the menu in the North! We’re happy to announce the Scandinavian RNA Club, a monthly hybrid hub and spoke seminar series on all things RNA between Stockholm, Uppsala and Tromsø starting January 2025! All RNA scientists, independent of career stage, research domain and place of work across Sweden and Norway, are welcome to join! Big thanks to the The RNA Society and Lexogen for making this series possible! You can find more details and sign up at: https://lnkd.in/dqaVCPcU   The seminar series is organized by Bastian Fromm (UiT, NO, https://lnkd.in/dedCN2Eg), Inna Biryukova (SU, SE, friedlanderlab.org/team) and Marcel Tarbier (UU, SE, https://lnkd.in/dVKwgt35). Thanks as well to our partners at SciLifeLab, Nordic Computational Biology (nordic-compbio.org), Stockholm University, UiT- The Arctic University of Norway and Uppsala University.

I had the opportunity to share my experience as a master's student in the Molecular Techniques in Life Sciences programme at Kungliga Tekniska högskolan, Stockholm University, and Karolinska Institutet. It has been a wonderful journey, connecting with peers to exchange ideas, learning from inspiring mentors, and being surrounded by incredible people advancing innovative approaches in omics at SciLifeLab 🤗 Grateful for the chance to be part of this scientific community! 👏

Great program! There will also be opportunities to exchange experiences at SciLifeLab ↓

10 innovative projects have received funding, as part of our 2024 Clinical Technology Development Projects call. Clinical Genomics Örebro is launching a project to implement shotgun metagenomics using long-read sequencing for faster sepsis diagnosis in ICU patients. This method aims to significantly reduce turnaround times for identifying pathogens and antibiotic resistance, addressing a critical gap in current diagnostics. “We hope this new approach will help ensure patients receive timely and effective treatment, which is essential for improving survival rates in these critically ill patients” says Bianca Stenmark, Head of Unit at SciLifeLab Clinical Genomics Örebro and Örebro University researcher. Follow the link to learn what e.g. Bernhard Schmierer (SciLifeLab CRISPR Functional Genomics) & Hans Blom (SciLifeLab Integrated Microscopy Technologies) intend to with their funds. https://lnkd.in/dh3HKa8K