A very fruitful time last Friday hearing from Prof Satish K Nair from University of Illinois Urbana-Champaign! Particularly, while AI and machine learning has greatly accelerated data analysis and generating predictive models in biological research, it is not without limitations. Prof Satish highlighted examples in his research where experimental data and structural analysis showed deviations from the models of such tools. Examples include the formation of non-productive complexes or conformational reorganisation after ligand binding–of which tools such as Alphafold were unable to show due to limited experimental data sets (eg. specific ligands). Are you into #machinelearning or #generativeAI for biological research and synbio applications? What are other problems faced and how can the players in the ecosystem collaborate to solve these problems? DM if you would like to connect! Thanks to NUS Yong Loo Lin School of Medicine Department of Biochemistry for co-organising this seminar! Wen Shan Yew
SINERGY, Singapore Consortium for Synthetic Biology
Biotechnology
SINERGY aims to consolidate Singapore’s capabilities in synthetic biology and harness synergies across industry sectors.
About us
SINERGY aims to consolidate Singapore’s capabilities in synthetic biology and harness synergies across industry sectors to create a vibrant and globally connected bio-based economy in Singapore. SINERGY is supported by the National Research Foundation and hosted at the National University of Singapore.
- Website
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https://www.sinergy.sg/
External link for SINERGY, Singapore Consortium for Synthetic Biology
- Industry
- Biotechnology
- Company size
- 2-10 employees
- Headquarters
- Singapore
- Type
- Educational
- Specialties
- synthetic biology, biotechnology, sustainability, and bioeconomy
Locations
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Primary
28 Medical Drive
Centre for Life Sciences
Singapore, 117456, SG
Employees at SINERGY, Singapore Consortium for Synthetic Biology
Updates
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Join us tomorrow at this SINERGY seminar at National University of Singapore, Department of Biochemistry!
Structural biology is a powerful tool for accelerating advancements in biocatalysis. Structural insights enable enzyme engineering with greater precision for increased enzyme efficiency and stability. By harnessing structural biology in biocatalysis, better enzymes potentially translate to better bio-based solutions for user-specific applications. Together with the Department of Biochemistry at NUS Yong Loo Lin School of Medicine, we are excited to welcome Prof Satish K. Nair from University of Illinois Urbana-Champaign, Department of Biochemistry, as he shares his team's work on applying structural biology methods to produce value-added compounds. Join us for this talk and a time of networking! 📅 4th Oct 2024 🕚 11.30am - 12.30pm (SG) 📍 NUS MD11 CRC Auditorium Check out more details 🔗 https://lnkd.in/gHQ3zxUi Register 🔗 https://lnkd.in/gzGRmJXA
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It was pleasure hearing from Jay Keasling on Monday, where he shared his insights on industrializing synthetic biology and building successful synbio companies. From therapeutics to consumer goods and food, realizing the potential to produce any compound with engineered microbes is closer than ever, driven by the speed and innovation of synthetic biologists. However, while the science is advancing rapidly, not every product can withstand economic and market pressures. Many synbio-based products come with a "green premium," and those products competing with petroleum or entering non-existent markets often struggle to survive. The key challenge lies in building processes that are economically viable. Furthermore, each country faces its own unique hurdles in biomanufacturing. As Jay aptly put it, "It's no longer about what can be produced, but what should be produced." It was fantastic to see many members of the synbio community, including Singapore Institute of Technology, A*STAR Singapore Institute of Food and Biotechnology Innovation (SIFBI) and NUS Synthetic Biology for Clinical and Technological Innovation (SynCTI). The Q&A session was engaging and thought-provoking. DM if you wish to connect or chat more! Susanna Leong
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Don't miss out on this SINERGY seminar with Jay Keasling at Singapore Institute of Technology next Monday! Do note a change in venue. See you there! Susanna Leong
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Structural biology is a powerful tool for accelerating advancements in biocatalysis. Structural insights enable enzyme engineering with greater precision for increased enzyme efficiency and stability. By harnessing structural biology in biocatalysis, better enzymes potentially translate to better bio-based solutions for user-specific applications. Together with the Department of Biochemistry at NUS Yong Loo Lin School of Medicine, we are excited to welcome Prof Satish K. Nair from University of Illinois Urbana-Champaign, Department of Biochemistry, as he shares his team's work on applying structural biology methods to produce value-added compounds. Join us for this talk and a time of networking! 📅 4th Oct 2024 🕚 11.30am - 12.30pm (SG) 📍 NUS MD11 CRC Auditorium Check out more details 🔗 https://lnkd.in/gHQ3zxUi Register 🔗 https://lnkd.in/gzGRmJXA
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Polyketide synthases (PKSs) are multifunctional enzymes which synthesize numerous pharmaceutical products such as antibiotics (e.g., erythromycin), cholesterol-lowering agents (e.g., lovastatin) and immunosuppressants (e.g., FK506). Engineering PKSs in a modular fashion at the DNA level allows the assembly of complex chemicals beyond those of pharmaceutical interest such as biofuels and commodity chemicals. In the upcoming SINERGY seminar hosted by Susanna Leong at Singapore Institute of Technology, Jay Keasling will be sharing his team's recent work on engineering PKSs for producing various specialty and fine chemicals. Jay is no stranger in the world of biotech, and has founded many companies such as Amyris, Lygos and LS9. If you have potential synbio technology to spin-off, join us for this exciting talk and networking over light lunch to glean from Jay's insights! Check out more details here: https://lnkd.in/gtRNV3S2 Register at: https://lnkd.in/gCEBYKAV See you on 30th Sep at Singapore Institute of Technology, 10am!
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It was a pleasure to have Jonathan Dordick from Rensselaer Polytechnic Institute share his team's work on the first bioengineered heparin produced through a synthetic biology-based process. The Heparin Crisis in 2008 presented a bioengineering opportunity to find an alternative source of heparin. More than a decade later, there is now a robust and scalable process to obtain heparin reliably. Nonetheless, scaling production and commercialization have their challenges. The motivation is to see bioengineered heparin take a similar path as recombinant insulin, which is now the only type of insulin approved for human use by the FDA. A wonderful time of networking and learning - Join us for future seminars to learn and discuss opportunities for collaborations! NUS Synthetic Biology for Clinical and Technological Innovation (SynCTI) 🔗 Check out a write up and link to the publication on bioengineered heparin here: https://lnkd.in/gawQs9CQ
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Synthetic biology is a critical technology to power the global #bioeconomy. Global conversations help to foster collaborations and position synbio to serve the greater good for positive impact. SINERGY's Director Matthew Chang has been involved in various international fora and will be speaking at the #TheSydneyDialogue next week! Check out more about the Australian Strategic Policy Institute and The Sydney Dialogue!
📣 NEW SPEAKER ANNOUNCEMENT 📣 In the lead-up to #TheSydneyDialogue on 2-3 September, we are delighted to announce that Matthew Chang, Executive Director of the Singapore National Centre for Engineering Biology, will speak at this year's event! Previously announced speakers include Co-founder and Chief Executive Officer of Rappler Maria Ressa, former Chief Executive Officer and Chairman of Google Eric Schmidt, New Zealand's Attorney-General and Minister of Defence the Hon Judith Collins KC MP, former Senior Advisor to United States Secretary of Defense Lloyd Austin Abraham Denmark and many more. Interested in attending #TSD2024? Register you interest now before submissions close ↪️ https://lnkd.in/gRWY9dbx
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SINERGY seminar with Jonathan Dordick is less than 5 days away! Don't forget to sign up and join us for this wonderful talk and networking.
Nature is a rich source of sulfated polysaccharides, which regulate key biological activities such as anti-coagulation, anti-inflammation and anti-viral. We are excited to have Institute Professor Jonathan Dordick from the Rensselaer Polytechnic Institute give a talk on his recent work on developing a synthetic biology-based process to produce heparin, an essential sulfated polysaccharide medicine and isolation of sulfated polysaccharides fractions from brown seaweeds which were highly potent against SARS-CoV-2. Find out more about this talk and Professor Jonathan Dordick from our website (https://lnkd.in/g4xJUv4A) 📅 26th August 2024 🕙 10.30am - 11.30am (SG) 📍 CeLS Auditorium, 28 Medical Drive #01-07 Join us for this exciting talk and a time of networking! 🔗 Register at https://lnkd.in/gADh3hs4 NUS Synthetic Biology for Clinical and Technological Innovation (SynCTI)