ACIES BIO Ltd.

𝐏𝐞𝐨𝐩𝐥𝐞 𝐨𝐟 𝐀𝐜𝐢𝐞𝐬: Helena Jalšovec, 𝐑𝐞𝐬𝐞𝐚𝐫𝐜𝐡 𝐒𝐜𝐢𝐞𝐧𝐭𝐢𝐬𝐭 𝐢𝐧 𝐌𝐢𝐜𝐫𝐨𝐟𝐥𝐮𝐢𝐝𝐢𝐜𝐬 Helena Jalšovec is a research scientist holding a PhD in biotechnology, currently working in the microfluidics department. She has several years of experience working at Acies, where she focused on microbiology and molecular biology field. This background now helps her to make valuable contributions to the field of microfluidic technologies. Here is what Helena has to say about working at Acies: 𝐖𝐡𝐚𝐭 𝐚𝐫𝐞 𝐲𝐨𝐮𝐫 𝐰𝐨𝐫𝐤 𝐚𝐜𝐭𝐢𝐯𝐢𝐭𝐢𝐞𝐬 𝐢𝐧 𝐲𝐨𝐮𝐫 𝐜𝐮𝐫𝐫𝐞𝐧𝐭 𝐫𝐨𝐥𝐞? “Working in the microfluidics department is never dull, as it encompasses a variety of projects and techniques. Some of my current tasks include: - developing assays for ultra-high throughput screening of strains for various purposes (such as faster growth, improved production, and enhanced enzymatic activity), - managing a project on μALE systems, - writing of project proposals.”   𝐖𝐡𝐚𝐭 𝐢𝐬 𝐲𝐨𝐮𝐫 𝐟𝐚𝐯𝐨𝐫𝐢𝐭𝐞 𝐚𝐬𝐩𝐞𝐜𝐭 𝐨𝐟 𝐲𝐨𝐮𝐫 𝐰𝐨𝐫𝐤? “The best aspect of my job is that my work is newer dull and monotonous and that I have the opportunity to engage in challenging projects that motivate me.”

We are being busy at BIOKET Bioeconomy Key Enabling Technologies platform conference! We see fermentation really being a key technology in Europe's Bioeconomy ,enabling new sustainable innovation. 🌍 Being in the middle of the conference we invite you once more to our 𝗯𝗼𝗼𝘁𝗵 𝗡𝗼.𝟵 𝗶𝗻 𝗵𝗮𝗹𝗹 𝟮 to discuss opportunities with our Bioprocess Director - Mirjan Švagelj an our BD Bor Klančnik! #BIOKET2025 #sustainability #bioeconomy #fermentation #CDMO

Looking forward to this event! It will be a privilege to host the hydrogen panel with renowned experts ✨ On the 2nd day of the event, we SRIP - Circular Economy are organising a circular bioeconomy tour to ACIES BIO Ltd., KANSAI HELIOS Group, GRASHKA and AquafilSLO. Interested French and Slovene colleagues are warmly invited! Johan DE CONINCK Anne Kokel Ruba Alabed Zamir Eldar Thomas Hemmerdinger Stephanie Morisset Bernard QUINET Thérèse Lam

𝐒𝐦𝐚𝐫𝐭𝐑𝐨𝐮𝐭𝐞 𝐭𝐨 𝐏𝐫𝐨𝐭𝐞𝐢𝐧𝐬: 𝐔𝐧𝐥𝐨𝐜𝐤 𝐭𝐡𝐞 𝐅𝐮𝐥𝐥 𝐏𝐨𝐭𝐞𝐧𝐭𝐢𝐚𝐥 𝐨𝐟 𝐏𝐫𝐨𝐭𝐞𝐢𝐧 𝐏𝐫𝐨𝐝𝐮𝐜𝐭𝐢𝐨𝐧 At Acies Bio, we offer a structured and efficient approach to 𝘉𝘢𝘤𝘪𝘭𝘭𝘶𝘴-based protein production, ensuring high titers, robust expression, and scalable bioprocesses. 𝐒𝐦𝐚𝐫𝐭𝐑𝐨𝐮𝐭𝐞 𝐭𝐨 𝐏𝐫𝐨𝐭𝐞𝐢𝐧𝐬 offers a three-phase process designed to streamline 𝐏𝐨𝐂 𝐝𝐞𝐯𝐞𝐥𝐨𝐩𝐦𝐞𝐧𝐭 𝐢𝐧 𝐥𝐞𝐬𝐬 𝐭𝐡𝐚𝐧 𝟑 𝐦𝐨𝐧𝐭𝐡𝐬 𝐭𝐢𝐦𝐞: 𝟏. 𝐁𝐚𝐜𝐢𝐥𝐥𝐮𝐬 𝐏𝐥𝐚𝐭𝐟𝐨𝐫𝐦 𝐈𝐧𝐭𝐞𝐠𝐫𝐚𝐭𝐢𝐨𝐧 ·       Suitability assessment to evaluate production feasibility ·       In silico prediction for optimized gene design ·       Sequence optimization for enhanced expression ·       Expert guidance on production technology development 𝟐. 𝐄𝐯𝐚𝐥𝐮𝐚𝐭𝐢𝐨𝐧 𝐏𝐡𝐚𝐬𝐞 ·       Fast and efficient assessment of protein production potential: ·       Expression level analysis for optimal host-protein pairing ·       Secretion capabilities evaluation to maximize extracellular yield ·       Titer potential assessment 𝟑. 𝐒𝐜𝐚𝐥𝐢𝐧𝐠 𝐏𝐡𝐚𝐬𝐞 ·       Bioprocess set-up tailored to production needs ·       Robustness testing to ensure large-scale process stability ·       Titer optimization up to 15 g/L for high-performance strains ·       Minimal media development for cost-effective production 𝐅𝐮𝐫𝐭𝐡𝐞𝐫 𝐝𝐞𝐯𝐞𝐥𝐨𝐩𝐦𝐞𝐧𝐭 𝐨𝐫 𝐂𝐌𝐎 For those seeking further improvements we can either license the technology, offer in-house CMO-based production or further development: ·       Additional strain optimization ·       Fine-tuning of genetic elements ·       Non-GMO strain improvement SmartRoute to Proteins provides a fast, efficient, and scalable path to industrial protein production. Contact us to explore how we can support your next breakthrough!

𝐁𝐮𝐬𝐲 𝐦𝐨𝐧𝐭𝐡 𝐚𝐡𝐞𝐚𝐝 𝐨𝐟 𝐀𝐜𝐢𝐞𝐬 𝐁𝐢𝐨! Here is a list of conferences that we will be attending in the following weeks: - World Agri-Tech - Martin Kavšček, Head of BD - BIOKET Bioeconomy Key Enabling Technologies platform - Bor Klančnik, from BD and Mirjan Švagelj, Head of Bioprocessing - Future Food-Tech - Martin Kavšček, Head of BD - 2025BioEx - 6th Biopesticides, Biostimulants and Biofertilizers Summit - Gregor Kosec, R&D Director Reach out to any of our attendees to connect and learn more about how Acies Bio develops new bioproducts and sustainable production processes for diverse industrial sectors.

𝐒𝐦𝐚𝐫𝐭𝐑𝐨𝐮𝐭𝐞™ 𝐭𝐨 𝐏𝐫𝐨𝐭𝐞𝐢𝐧𝐬 – 𝐒𝐮𝐜𝐜𝐞𝐬𝐬 𝐒𝐭𝐨𝐫𝐲 𝐢𝐧 𝐏𝐫𝐨𝐭𝐞𝐢𝐧-𝐁𝐚𝐬𝐞𝐝 𝐂𝐫𝐨𝐩 𝐏𝐫𝐨𝐭𝐞𝐜𝐭𝐢𝐨𝐧 At Acies Bio, we are committed to accelerating the development of protein production, ensuring sustainable and efficient solutions. With more than 20 successfully expressed proteins, here’s one example of our SmartRoute™ to Proteins platform making a difference in the AgBio sector: 𝐏𝐑𝐎𝐁𝐋𝐄𝐌: The demand for efficient and scalable production of protein-based biopesticides is growing, yet many solutions remain limited by low yields, long development times, and challenging scale-up. 𝐒𝐎𝐋𝐔𝐓𝐈𝐎𝐍: With our SmartRoute™ to Proteins, we provide a streamlined path from proof-of-concept (PoC) to industrial-scale manufacturing. Combining strain engineering, bioprocess optimization, and scalable fermentation strategies, we accelerate development while maximizing protein titers. 𝐑𝐄𝐒𝐔𝐋𝐓𝐒: In just 3 months, we achieved up to 15 g/L of secreted protein, significantly surpassing conventional development timelines and demonstrating the efficiency of our platform. 𝐅𝐔𝐓𝐔𝐑𝐄 𝐃𝐄𝐕𝐄𝐋𝐎𝐏𝐌𝐄𝐍𝐓: Additionally, we can push yields even further, ensuring that industrial-scale production is both efficient and cost-effective for large-scale applications.

𝐁𝐢𝐨𝐭𝐞𝐜𝐡 𝐦𝐞𝐞𝐭𝐬 𝐜𝐫𝐞𝐚𝐭𝐢𝐯𝐞 𝐝𝐞𝐬𝐢𝐠𝐧! At Acies Bio, we love seeing biotechnology push creative boundaries. We were proud to scale up the 𝘚𝘵𝘳𝘦𝘱𝘵𝘰𝘮𝘺𝘤𝘦𝘴 𝘤𝘰𝘦𝘭𝘪𝘤𝘰𝘭𝘰𝘳 pigment for Loops, a felted carpet project exploring birth, decay, and rebirth - supported by the British Council. This unique collaboration brings together: - Hana Cvelbar, 3D printing, engineering, molecular and synthetic biology expert, and co-founder of Ancient Futures - Asel Yeszhanova, an architect and social activist - Dana Molzhigit, biomaterials researcher, designer, entrepreneur, and co-founder of Ancient Futures - Center Rog Creative Hub , project partner We are happy to play our part in bridging science and art for a unique and sustainable future!

The EU is shifting focus from research to scale-up and implementation, reinforcing Europe's competitiveness and impact. On April 4th, Pilots4U by CoPilot’s 𝐄𝐮𝐫𝐨𝐩𝐞𝐚𝐧 𝐏𝐢𝐥𝐨𝐭 𝐚𝐧𝐝 𝐃𝐞𝐦𝐨𝐧𝐬𝐭𝐫𝐚𝐭𝐢𝐨𝐧 𝐈𝐧𝐟𝐫𝐚𝐬𝐭𝐫𝐮𝐜𝐭𝐮𝐫𝐞 𝐅𝐚𝐢𝐫 will be held in Belgium, Brussels. This event is co-organized by Circular Bio-based Europe Joint Undertaking (CBE JU), following the CBE JU Info Day 2025 (April 3rd), both of which Acies is excited to attend. We see this as a great opportunity to connect and gather insights into bioeconomy scale-up services!

The EU is shifting focus from research to scale-up and implementation, reinforcing Europe's competitiveness and impact. On April 4th, Pilots4U by CoPilot’s 𝐄𝐮𝐫𝐨𝐩𝐞𝐚𝐧 𝐏𝐢𝐥𝐨𝐭 𝐚𝐧𝐝 𝐃𝐞𝐦𝐨𝐧𝐬𝐭𝐫𝐚𝐭𝐢𝐨𝐧 𝐈𝐧𝐟𝐫𝐚𝐬𝐭𝐫𝐮𝐜𝐭𝐮𝐫𝐞 𝐅𝐚𝐢𝐫 will be held in Belgium, Brussels. This event is co-organized by Circular Bio-based Europe Joint Undertaking (CBE JU), following the CBE JU Info Day 2025 (April 3rd), both of which Acies is excited to attend. We see this as a great opportunity to connect and gather insights into bioeconomy scale-up services!

𝐏𝐞𝐨𝐩𝐥𝐞 𝐨𝐟 𝐀𝐜𝐢𝐞𝐬, Zan Blagotinsek 𝐀𝐬𝐬𝐨𝐜𝐢𝐚𝐭𝐞 𝐁𝐢𝐨𝐩𝐫𝐨𝐜𝐞𝐬𝐬𝐢𝐧𝐠 𝐄𝐧𝐠𝐢𝐧𝐞𝐞𝐫 Meet Žan Blagotinšek, an Associate Bioprocessing Engineer in the Pilot Plant Department of the Bioprocessing Business Unit at Acies Bio. Currently completing his MSc in Microbiology, Žan brings expertise as a shift leader in large-scale fermentation processes, including downstream operations and upscaling initiatives. Here is what Žan has to say about working at Acies: 𝐖𝐡𝐚𝐭 𝐚𝐫𝐞 𝐲𝐨𝐮𝐫 𝐰𝐨𝐫𝐤 𝐚𝐜𝐭𝐢𝐯𝐢𝐭𝐢𝐞𝐬 𝐢𝐧 𝐲𝐨𝐮𝐫 𝐜𝐮𝐫𝐫𝐞𝐧𝐭 𝐫𝐨𝐥𝐞? »As an Associate Bioprocessing Engineer, I focus on overseeing and optimizing fermentation processes at a large scale. My tasks include: - leading shifts to ensure operational excellence in fermentation processes - collaborating with cross-functional teams for process optimization and scaling up - monitoring and troubleshooting bioprocess systems to maintain high standards of quality and efficiency«   𝐖𝐡𝐚𝐭 𝐢𝐬 𝐲𝐨𝐮𝐫 𝐟𝐚𝐯𝐨𝐫𝐢𝐭𝐞 𝐚𝐬𝐩𝐞𝐜𝐭 𝐨𝐟 𝐲𝐨𝐮𝐫 𝐰𝐨𝐫𝐤? »My favorite aspect of working at Acies is witnessing the real-time impact of innovation and teamwork in transforming concepts into scalable bioprocesses. It’s rewarding to see the tangible outcomes of our efforts in creating sustainable and efficient solutions.«