I've encountered no compatibility issues on Windows 11, running the game with no mods or adjustments. It's known for being unstable and I've had some seemingly completely random crashes a few times, though the game autosaves every time you do anything noteworthy, so it's not a huge deal. You saw my post about dealing with the persistent crash that may occur after some missions - from what I've read, it seems like this issue pops up randomly and different people encounter it at different points or not at all.

The only advice I can give about avoiding the more random crashes is not to use "super fast travel" when in an interior - the game doesn't seem to like that.

If you're just getting started, I highly recommend disabling depth of field to make the game look a million times better. I suppose it's there to hide the object pop-in, but it just looks horrendous in my opinion.

Good deal. Thanks for the tips.