"If there's anything you want—anything at all... come to me. I'll be your guardian angel."

Texhnolyze (stylized as ＴＥＸＨＮＯＬＹＺＥ) is a Japanese experimental anime television series animated by Madhouse and directed by Hiroshi Hamasaki, with screenplay by Chiaki J. Konaka, with original character design by Yoshitoshi ABe and produced by Yasuyuki Ueda. It was broadcast on Fuji Television and its affiliates from April to September 2003.

In the not-too-distant future, deep underground, descendants of a banished generation vie for control of the crumbling city of Lux. Ichise, an orphan turned prize fighter, loses an arm and a leg to satisfy an enraged promoter. On the brink of death, he is taken in by a young female doctor and used as a guinea pig for the next evolution of texhnolyze.

The story takes place in the vibrant yet dilapidated underground city of Lux. Denizens of Lux have come to call it "The City" and treat it as a sentient force. It focuses on Ichise, a stoic prize fighter who loses a leg and an arm to satisfy an enraged promoter; Onishi, a young but level-headed executive who has many enemies; and Ran, a little girl who has a very important gift that affects the entire city. As they struggle to accept the challenges that they are dealt, they bear witness to major events that determine the survival and fate of the city.

Having adjusted to his new limbs, Ichise is eventually taken under the wing of Onishi, the powerful but distrusted leader of Organo, a criminal organization with some hold over the people of Lux. Meanwhile, four different factions begin to draw battlelines for territorial control of the city: the aforementioned Organo; the Union, a fiercely anti-texhnolyze faction; the Racan, a group of rebellious texhnolyzed youths; and the Class, a mysterious group of privileged beings who lurk behind the city. As Ichise is unwillingly drawn deeper into an uncontrollable war, he learns of his possible future from the prophet girl Ｒａｎ, who guides him from the shadows in his darkest times. When society comes crashing down, Ichise must uncover the truth about Lux and fight for his survival.

Directed by Hiroshi Hamasaki, written by Chiaki Konaka with character design by Yoshitoshi ABe and animated by Madhouse, ＴＥＸＨＮＯＬＹＺＥ is often considered to be one of the strangest and darkest anime ever made.