Since this only worked to a very limited extent and not really 100% with the mouse acceleration via windows, I looked for an effective, 100% solution. The depth of field also bothered me extremely, which is very noticeable in some situations. I also managed to disable chromatic aberration.

Disable mouse acceleration in windows if you have it enabled, my in-game guide now fixes this.

I have now tested the one std in different situations of the game, and the camera control now works 100% with the mouse. As well as depth of field and chromic aberration are completely disabled.

To do this, proceed as follows:

Open steamapps/common/Uncharted4_data/screeninfo.cfg

Now add the following to the bottom line:

DepthOfField=0
FastBlur=0
ChromaticAberration=0
MouseAcceleration=1
MouseHorizontalSpeed=100
MouseVerticalSpeed=100
CameraHorizontalSpeed=100
CameraVerticalSpeed=100

Save and close.

Now comes the most important thing so that the settings are not deleted from the game and also work permanently: Click on properties in screeninfo.cfg and activate: Read-only.

This is very important, otherwise the game will delete the settings after you start the game. As I said, these entries work 100%.

Should there be a patch for the mouse, simply remove the mouse and camera entry and set it back to read-only for the deactivated blur effects.

Have fun.