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Lastly, you could also pre-use the 500 pill right before you head into an intense gunfight since the pill also gives you extremely powerful regeneration as one of its effects for a short time. If you pop pill just before a gunfight, that regeneration could give you a huge advantage and make certain situations more winnable as a result.
Green Candy doesn't explicitly protect you from negative status effects, it actually gives you mild regeneration for a quite long period of time. If you're able to get yourself a coke, eating a green candy shortly after drinking the coke is an excellent synergy as the regeneration provided by green candy actually out-paces the damage you receive as a side effect from drinking coke, which effectively extends how long you can safely use coke by roughly a minute. It's also just good to have that gradual healing if you took some damage but aren't in a dangerous situation where using a more immediately potent healing item will be necessary.