First of all, read this all careful, as you will miss some important Information and may get bad experience if you tweak your INIs wrong.

Don't use my preset recommendations for legacy Skyrim for this version of the game but the one here on Nexus[www.nexusmods.com].

On November 11, 2021 Bethesda will release the Skyrim Anniversary Edition with contend from Creation Club included. More details here[bethesda.net]. If you don't want this will be installed automatically, make sure you have disabled auto-update in the properties of your Steam Client. Bethesda used Visual Studio 2019 as a compiler for this new game. Therefore it is very likely, that your mods, which using DLLs, are not compatible anymore and will not work after upgrading to new version.

Before you start to tweak your INIs, save and backup your current INIs. May be you first start opening yours and then choose one from my presets and compare it in Notepad and edit yours.

If you're using an AMD Radeon graphics card, use the currently new final release, or even better Adrenalin 20.x. When you use the new AMD Radeon Adrenalin Edition, take care you defined the game settings for Skyrim as mentioned before, as adjusting AMD game profiles is different as before with CCC. You are now able to adjust the predefined profiles in the new AMD Radeon Adrenalin UI.

But keep in mind, that usage of VRAM on Win8 and Win10 is still limited for DX9 games up to 4GB only, not higher as it was possible with Win7. The recent version of Windows 10 (starting with 1703 Build 15063.13 and higher) gives you a bit more with the new integrated game mode, which gives your game more priority on resources and the VRAM limit for DX9 games has been removed. With Skyrim V Special Edition, general memory issue has significantly changed, as this remastered version of the game is a 64-bit application supporting DirectX 11, which enables use of more memory. Famous modders are also prepared to change and working on their mods to match and make them compatible with the new version. There have been made also major changes for the LOD system, which solves all legacy uGridsToLoad and referencing scripting issues.

You need to set your graphics card Anti-Aliasing methode to SuperSampling and AA to 8x or 8xEq and option to overwrite application settings (if you use any ENB presets, you have to leave your graphics card to use application settings) , and disable the two options FXAA or TAA on the SkyrimPresf.ini section [Display] with bUseTAA=0 and bFXAAEnabled=0 (same settings as switching Anti-Aliasing to off in SkyrimLauncher) and you get better graphics experiences without this.

So additionally you have to enable Anisotropic-Filter on your graphics card settings with level 16x and option to overwrite application/game setting (except you use any ENB preset). If you use my own INIs, you have to do this, as I have switched them all off on my settings and get better graphics and performance experience without this blurry scenarios.

But, starting with Windows 10 Version 20H1 the operating system (OS) applies the graphics processor (GPU) to applications. That means, the profile settings from GPU vendors are overwritten. Only if the OS has no GPU settings for an application, GPU vendors settings will be applied.

When you use one of my presets, watch the INIs special sections as mentioned below on this text and edit it with the values from your own backup INIs, especially the values in regards of your language and graphics device, otherwise it will be reset by default Skyrim in-game configuration.

Remember to change your graphics reference in the SkyrimPrefs.ini under [Launcher] section (sD3DDevice=) and on the [Display] section your display resolution (iSize H / iSize W). Otherwise the game will overwrite the whole INI. You must also check the language setting on [General] section (sLanguage=) in the Skyrim.ini, otherwise the Steam game management will start downloading the languages files for this language. And on the Skyrim.ini under [Archive], there is a localized voices_*0.bsa. You better compare your own Skyrim.ini on this section.

Mod Organizer and some other mod manager tools like STEP makes and uses its own Skyrim.ini and Skyrimprefs.ini located at Mod Organizer/profiles/your profiles name. So be aware to replace or change the right INIs to get your results.

For game content fixes it is recommended to use Unofficial Skyrim Patches, mainly USSEP[www.nexusmods.com]. Most of Arthmoor's mods are also available in other languages to match your game language you use.

My recommended graphics mods:
Mods from ramccoid[www.nexusmods.com]
Mods from Gamwich[www.nexusmods.com]
Mods from raiserfx[www.nexusmods.com]

My recommended follower mods:
Rigmor of Bruma by Rigmor
Sofia - The Funny Fully Voiced Follower by John Jarvis and Christine Slagman
Vilja in Skyrim by Emma Amgepo Lycanthrops
Recorder - Standalone Fully Voiced Follower by potasticpanda
Caesia Follower by Miroslav - Anbeegod
Ambriel - The Lost Princess SE by Excelsior2000
Hel Rising by nachtdaemmerung77

If you want to use any weather or lighting mods, follow this recommendation for installation order:
Weather mods (Dolomite Weathers - Natural Lighting Vivid Atmospherics II by Dr Mega and Kojak)
Relighting Skyrim (Relighting Skyrim - SSE by --JawZ-- and NovakDalton)
Interior lighting mods (Enhanced Lighting for ENB (ELE) - Special Edition by --JawZ--)

ELE and RS don't do the same, so no overwrites should occuring and for Dolomite there shouldn't be any overwrites either as it is confirmed to be compatible.
Recommended settings for Dolomite Weathers INI settings which comes with the mod, look into your games data directory

[Display]
fGlobalSaturationBoost=-0.2 ;default -0.13, recommended -0.2, that reduces saturation to somewhere between the natural and vivid versions. -.2 is around the natural version, 0 is the vivid

Use load order from LOOT. Latest version which support Skyrim SE here[www.nexusmods.com]. Check the thread on LOOT and get the newest version, but read the release notes if you upgrade.
BTW, this version of Skyrim is more sensible removing mods during a play through. You will get a broken savegame if you remove mods you have had enabled before.

And if you want to use SkyUI[www.nexusmods.com], you will need SKSE64[skse.silverlock.org].

And if you use SKSE64, you need to start your game with SKSE64_Loader.exe, that also means, you need to add this to your profiles for your graphics card and the above mentioned settings for AA and AF, otherwise the filter may not be loaded if you start the game this way.

For breast, belly and butt physics you need SKSE64 too. And you need CBP Physics mod[www.nexusmods.com] or to consider collisions also, prefer CBPC Physics mod[www.nexusmods.com].

If you want to try an ENB preset, look at Sin Xtreme Realism ENB by L3st4t.

Or follow Vivid Skyrim mod recommendations by Merkcy.

And for your optimal modification installation and load order, use
Skyrim S-E-P-T-I-M Guide from zackalope