Gen Era Diagnostics

🧬 Every Cancer Has a Story—TMB Helps Us Read Between the Lines!🧬   Tumor Mutational Burden (#TMB) sheds light on how likely a tumor is to respond to immunotherapy, helping personalize treatment strategies. Clinical trials have demonstrated that high TMB levels correlate with improved outcomes in multiple cancers.   🔬 How is TMB Measured? 🔹 Whole Exome Sequencing (WES): Offering a comprehensive view of mutations, but costly and resource-intensive. 🔹 Targeted Gene Panels: Cost-effective and clinically practical, allowing simultaneous assessment of multiple biomarkers. (e.g., Archer VariantPlex® Complete Panel). 🔹 MSI & HRD Testing: Complements use of large targeted panels particularly in cancers like colorectal, breast, and ovarian cancers. 🔹 SNP Arrays & LOH Analysis: Evaluates genomic instability, often combined with telomere analysis for a broader molecular profile.   🧬 The Integrated DNA Technologies Archer VariantPlex® Complete Panel enables accurate TMB estimation alongside MSI, HRD, and LOH detection, supporting #immunotherapy decisions with comprehensive genomic profiling. Find the details here: https://lnkd.in/ePeRhN9C   As #oncology advances, integrating TMB with multi-biomarker testing guides immunotherapy decisions and improves patient outcomes.   👉 Want to learn more? Reach out to us today! info@gen-era.com.tr

🌟 NGS and Pathology? We had a lot to say at PAKO 2025! 🌟   This past weekend at the 15th Pathology Winter School was all about molecular pathology in practice. With case discussions and method presentations, it felt like a hands-on learning experience! Alongside these discussions we had the chance to bring NGS into the conversation, highlighting its role in molecular diagnostics and clinical decision-making.   📌 On the first day, Can Holyavkin started off with a solid introduction to next-generation sequencing (NGS), laying the groundwork for understanding its technical and analytical aspects in molecular pathology.   📌 Assoc. Prof. Ibrahim Kulac and M. Çisel Aydın MD continued on the second day by taking it a step further, explaining how NGS is applied in daily clinical practice. Their real-world examples helped put everything into perspective and showed how sequencing is shaping molecular pathology.   It was also a great opportunity to exchange ideas and connect with colleagues. Thanks to the organizers, speakers, and everyone who participated—looking forward to the next one!   #MolecularPathology #NGS 

🩺 Bilimden İlham Alan Sağlık Kahramanlarına! 🩺   Bugün sağlığımız için özveriyle emek veren, hayatlarını insan sağlığına adamış tüm hekimlerimizin ve sağlık çalışanlarımızın Tıp Bayramı’nı kutluyoruz!   Doktorlar, araştırmacılar, laboratuvar uzmanları ve sağlık personelleri olarak, sağlık sektörüne ve insanların yaşamına kattığınız değer paha biçilemez.   Daha sağlıklı bir toplum, daha iyi bir gelecek için bilimden ve yenilikçi çözümlerden aldığımız güçle her zaman sağlık profesyonellerimizin yanında olmaya devam edeceğiz.   Her gün sayısız yaşama umut olduğunuz için teşekkür ederiz. 👏✨   #14Mart #TıpBayramı

🌟 We will be there! Let’s talk NGS at PAKO 2025 🌟   A must-attend event for professionals and residents in the field: 15th Pathology Winter School organized by the Ankara Pathology Association. And we are taking the stage with two insightful talks on #NGS; 🗓 March 15, 2025 🕒 16:30-17:00 – NGS: Fundamental Molecular Principles – Can Holyavkin   🗓 March 16, 2025 🕒 12:00-13:00 – NGS Practice Through Case Studies – Assoc. Prof. Ibrahim Kulac & Dr. M. Çisel Aydın This exclusive event is set to be a valuable platform for advancing #genomics discussions. 👉 Stay tuned as we bring highlights from the sessions!

🧬 Can We Classify Tumors More Precisely? Methylation Profiling Says Yes! 🧬   For sarcomas and central nervous system (#CNS) tumors, accurate classification is critical for selecting the right treatment approach.    While traditional methods rely on histopathology, methylation profiling provides a deeper molecular perspective, offering more precise classification based on the #WHO 2021 CNS tumor guidelines.   The Illumina Infinium MethylationEPIC v2.0 BeadChip (Methylation Array) enables DNA methylation-based tumor classification using DKFZ’s advanced software, helping to identify tumor subtypes that may not be distinguishable under a microscope.   ✅ Why is this important for clinical practice? 🔹 Differentiates tumors with similar histology but distinct clinical outcomes, 🔹 Enhances diagnostic accuracy, reducing uncertainty in complex cases, 🔹 Enables retrospective analysis with FFPE sample compatibility, 🔹 Supports better-informed treatment strategies with molecular insights.   👉 Methylation profiling is shaping the future of oncology, offering a more refined approach to tumor classification.  Read to explore how: 🔗https://lnkd.in/d3FV7xhS #Oncology #illumina

🔬Looking to Upgrade Your Lab Workflow? Meet Hamilton Microlab® Prep™! 🔬 In modern laboratories, precision, efficiency, and reproducibility are non-negotiable. Whether you're working in molecular biology, genomics, drug discovery, or clinical diagnostics, automation is the key to unlocking higher throughput and consistency. A compact yet powerful pipetting workstation designed to handle critical lab workflows with ease; 💡 Why Hamilton Robotics Microlab® Prep™? ✅ Customizable Configurations – Choose 2 independent pipetting channels, an 8-channel multi-probe head, or both for optimal flexibility. ✅ CO-RE® Technology & Air Displacement Pipetting – Ensures precise tip attachment with no liquid-filled systems, reducing contamination risks. ✅ Intelligent Labware Detection – Built-in camera automatically recognizes labware, simplifying protocol setup. ✅ User-Friendly Touchscreen – Intuitive, smartphone-like interface allows seamless protocol programming. ✅ Small Footprint, Big Impact – A compact 3-square-foot design that fits any lab bench without compromising performance. 🔍 Who Can Benefit? From genetic testing labs to biopharmaceutical R&D, clinical diagnostics, and academic research, Microlab Prep adapts to your workflow—enhancing efficiency, reducing errors, and freeing up valuable time for scientific discovery. 👉 Upgrade your lab with Hamilton Microlab Prep and experience automation designed around you! Contact us for more details: info@gen-era.com.tr 📩 #HamiltonRobotics #LabAutomation #Genomics

🧬HRD Detection Made More Accessible with GIINGER™ Algorithm by SOPHiA GENETICS🧬 #HRD (Homologous Recombination Deficiency) is a crucial biomarker guiding #PARP inhibitor (PARPi) therapy in cancer treatment. Traditionally, comprehensive genomic profiling is needed to assess HRD status, often requiring high-depth sequencing. However, an innovative approach—GIINGER™—is redefining HRD detection by leveraging low-pass whole genome sequencing data. 📊 A recent study highlights that SOPHiA DDM HRD Dx Solution using GIINGER™ algorithm shows >94% concordance with Myriad’s HRD assessment, demonstrating its potential as a cost-effective and scalable alternative for HRD testing👇.  Find the article here: https://lnkd.in/dRMgssfU Increase access to HRD testing in clinical setting; ✅ Low-pass WGS: Reduces sequencing depth and cost without compromising reliability. ✅ Predict PARP Inhibitor Response: Effectively identifies patients who may benefit from targeted therapy. ✅ CE-IVD Certified: Available for in vitro diagnostic use in the European Economic Area (EEA), UK, and Switzerland via SOPHiA DDM™ Dx HRD Solution. 📌 #ESMO Precision Medicine Working Group recommends SOPHiA DDM Dx HRD Solution as a validated method for detection of HRD: https://lnkd.in/ddpmyseg

🔬 Science Thrives on Talent—Are We Using All of It? 🔬   Throughout history, women have made groundbreaking contributions to science, yet their representation and recognition still lag behind.    Rosalind Franklin’s role in uncovering DNA’s structure, Marie Curie’s pioneering work in radioactivity, and Emmanuelle Charpentier and Jennifer Doudna’s CRISPR breakthrough—these are just a few names among many who shaped the scientific world.   👉But here’s a question: How can science reach its full potential without equal opportunities for all minds?   📉 The Reality: -Women still face barriers in leadership roles across scientific institutions. -Their scientific work receives fewer citations on average. -Despite equal scientific performance, structural barriers and implicit biases slow women's promotions in academia, directly contributing to the wage gap. Science is strongest when diverse perspectives contribute to discovery. We believe in fostering an inclusive research environment where all talent is recognized and supported.    Thank you to all the incredible women at Gen Era team! Your contributions strengthen the impact we create.💪 Let’s work towards a future where scientific potential is defined by ability, not by gender.   📢 Happy International Women’s Day!   #WomenInScience #InternationalWomensDay

🎗️ Let's talk about Colon Cancer this month - Screening Matter! 🎗️   A leading cause of cancer-related deaths: Colon Cancer.    But do you know that it is also one of the most preventable cancers? Up to 90% of cases can be prevented through early detection, screening, and genetic testing.   Why Genetic Testing is Critical? 🧬 About 10% of colorectal cancers are hereditary, often linked to conditions like #LynchSyndrome or familial adenomatous polyposis (FAP). 🧪 Genetic testing helps identify individuals at higher risk, enabling early screening and preventive strategies for them and their families. 🔍 If you have a family history of colon cancer or related genetic conditions, speak to a healthcare provider about personalized screening options.   From awareness to action: What is the role of healthcare providers? 🔹 Identify high-risk patients early – Integrating genetic testing into routine assessments can refine screening strategies. 🔹 Bridge the gap between genetics and prevention – A multidisciplinary approach enhances personalized care and intervention. 🔹 Drive compliance, save lives – Educating patients on screening adherence reduces late-stage diagnoses and improves outcomes.   👉 This March, let’s emphasize the importance of proactive screening and genetic risk assessment in clinical practice.   #ColonCancerAwareness #GeneticTesting

🎥 The New Episode is Out! Expert insights into NGS: Neurology 🎥   This time we explore the groundbreaking role of NGS in neurodegenerative diseases.   Prof. Dr. Can Ebru Kurt shares how gene therapy is transforming the treatment landscape for conditions like #SMA. With gene replacement therapy, children who have lost their ability to walk may regain mobility—a remarkable advancement. For these treatments to be effectively applied, genetic testing is crucial now.   Beyond SMA, gene silencing therapies are now being applied to #ALS, unlocking new possibilities for treatment. Previously, many neurological diseases could only be diagnosed, with no effective therapeutic options. Now, NGS is changing that by enabling personalized treatment strategies.   🧬 Why it Matters: Genetic diagnosis is no longer just about identifying diseases—it is shaping therapeutic possibilities. #NGS is essential for every lab, revolutionizing the way we approach neurodegenerative diseases.   👉 Watch the full video now: https://lnkd.in/du2tg4ZM #Neurology #NeurodegerativeDiseases