BioAscent

The compound management team at BioAscent has expertise in data management, software development and logistics, all working in state-of-the-art facilities based at Newhouse in Scotland. Find out more about our compound management expertise here: https://lnkd.in/eCAgKwe9 #IntegratedDrugDiscovery #CompoundManagement

We're hiring: Organic and Medicinal Chemists - Scientists and Senior Scientists. We are currently seeking experienced organic and medicinal chemists to join BioAscent's chemistry team. Key responsibilities include: - Applying and developing synthetic and medicinal chemistry skills at the cutting edge of scientific research - Designing, planning, and executing complex synthetic routes for customer drug discovery projects - Collaborating and helping to solve challenging problems with our customers, from hit identification through to preclinical and clinical candidates across all biological target classes and major therapeutic indications We have multiple permanent and fixed-term opportunities available and welcome applications from experienced organic chemists at various levels, PhD qualified scientists and seasoned Drug Hunters. Click here to find out more and apply: https://lnkd.in/eJKFKZDE Please note, that the closing date for applications is 4 April 2025 with interviews planned for soon after. #IntegratedDrugDiscovery #Vacancy #ScienceJobs #ScotlandJobs #WeAreHiring

Strengthening BioAscent's mitochondrial biology capabilities. BioAscent's latest investment in a state-of-the-art Seahorse XF Pro Analyser Platform is set to revolutionise our approach to addressing bioenergetic questions and enhancing our understanding of cellular metabolic functions. Find out more about the equipment and how it will play a key part in studying specific metabolic pathways and signaling mechanisms: https://lnkd.in/eww3X5rd #MitochondrialBiology #IntegratedDrugDiscovery

Meet the BioAscent team at the RSC BMCS. Let us accelerate your project! #medicinalchemistry #drugdiscovery

BioAscent is the chosen provider of compound management services to over 70 customers across the globe. Our customers recommend our fast and flexible service when it comes to our compound management service. To find out more about our compound management expertise, click here: https://lnkd.in/eCAgKwe9 #DrugDiscovery #CompoundManagement

Day two of an inspiring customer visit in Gothenburg! Collaborating closely, we delved into discovery projects aimed at transforming healthcare for the better. These moments of shared vision and creativity remind us why we do what we do—to improve lives through impactful partnerships. Here’s to the power of collaboration with BioAscent ##DrugDiscovery #DiscoveryProjects

Thank you to everyone who stopped by to speak with Associate Scientists Nikita Shvedov and Ana Rita Pereira at the University of Glasgow's Kickstart Your Career in Life Sciences career fair today. Nikita and Rita, who successfully completed 12-week placements at BioAscent before returning as full-time employees, enjoyed sharing their experiences and speaking about BioAscent, Scotland’s largest drug discovery and compound management contract research organisation. #UofGMVLS #LifeSciencesCareers #IntegratedDrugDiscovery

The University of Glasgow's Kickstart Your Career in Life Sciences careers fair begins today. If you're keen to find out more about career options in life sciences after graduation, be sure to speak to BioAscent Associate Scientists Nikita Shvedov and Ana Rita Pereira. Both Nikita and Rita successfully completed 12-week placements at BioAscent before returning as full-time employees. Meet them on Monday 17 March to hear about their experiences and to find out more about BioAscent, Scotland’s largest drug discovery and compound management contract research organisation. #UofGMVLS #LifeSciencesCareers #IntegratedDrugDiscovery

The RSC BMCS Symposium on Mastering Medicinal Chemistry begins today at Burlington House, London. Senior Scientists Andrew Neal and Mark Grafton are attending and will be available to answer any questions delegates may have about our services. If you would like to arrange a meeting, please get in touch by emailing info@bioascent.com. Find out more about the symposium here: https://lnkd.in/ejFMHNAK #MasteringMedChem25 #Event #Networking #IntegratedDrugDiscovery

It takes a village to discover a drug… I’m thrilled to see our work on the development of cyclophilin inhibitors for the treatment of MASH liver disease published in the Journal of Medicinal Chemistry (ACS Publications). Our team used FEP modelling to design and synthesize novel, potent, and selective Cyclophilin B inhibitors with strong efficacy in a MASH cellular model—comparable to Resmetirom, the only FDA-approved treatment to date (which is only effective for 1 in 4 patients) —along with a favourable in vitro DMPK profile. One step closer to in vivo proof of concept! This was a large collaborative effort led by the University of Edinburgh School of Chemistry, with support from the the Edinburgh Protein Production Facility (University of Edinburgh School of Biological Sciences), the Centre for Cardiovascular Sciences and the Institute for Regeneration and Repair (College of Medicine & Veterinary Medicine, The University of Edinburgh) and several industrial partners mentioned below. I would especially like to acknowledge my academic collaborators, Alison Hulme and Dahlia Doughty Shenton, without whom this work would never have seen the light of day. A huge thank you to our industrial collaborators that helped moved the project forward at different stages: 🔹 Cresset – for access to Flare FEP; it was fun being a software user for once! 🔹 BioAscent– for organic synthesis support; you got us here so much faster! 🔹 Cytochroma– for testing our compounds in your hepatocyte steatosis assay; your iPSC-derived hepatocytes are amazing! 🔹 Concept Life Sciences– for the cell imaging analyses—Figure 5D says it all! 🔹 Eurofins– for the extensive DMPK-Tox studies that taught us so much about our compounds. Finally, thanks to the European Research Council (ERC), EastBio DTP, and the The University of Edinburgh for funding this work. 🔗 Read the full paper here: https://lnkd.in/eZS9g7Kh