CHARM Therapeutics

We’ve just released our latest preprint, “Leveraging Alchemical Free Energy Calculations with Accurate Protein Structure Prediction” - introducing a novel approach to Free Energy Perturbation (FEP) that transforms lead optimisation in early drug discovery.   In a new blog, Jan Domanski, PhD, VP Platform, explores how we are integrating FEP with DragonFold, our proprietary AI-driven protein-ligand prediction platform. This advancement improves accuracy while eliminating labour-intensive setup steps involved with traditional methods, making drug discovery faster and more scalable.   Read our blog to learn more about how we're innovating computational drug design: https://lnkd.in/d5g_b4EP   You can also explore our preprint here: https://lnkd.in/dHq4t8Qu   #AI #DrugDiscovery #DeepLearning #Biotech

Our Chief Business Officer Dr Beverley Carr and Director, Translational Pharmacology, Amanda Kennedy, PhD were at the BioIndustry Association (BIA) #WomeninBiotech event which took place in Cambridge last week to celebrate #InternationalWomensDay!   They joined over 250 other life science leaders to connect with and support each other. Keynote speaker Dr Stephanie Kuku, MD emphasised the importance of diversity representation in AI industries, a topic that is central to how we engage in AI-enabled drug discovery at CHARM.    #IWD2025 #WomenInLeadership

Saturday is International Women’s Day!   At CHARM Therapeutics, we continue to celebrate the contributions women continue to make in science and leadership.   To mark the day and conclude our Women in Leadership series, we’re spotlighting Sarah Skerratt, FRSC, Ph.D., Chief Scientific Officer at CHARM.   We spoke to Sarah about what International Women’s Day means to her and any advice for young women pursuing a career in STEM.   At CHARM, we are committed to fostering a culture that not only supports but actively empowers women to thrive in leadership, science, and innovation. Here’s to the incredible women at CHARM and around the world who continue to break barriers and drive change!   #InternationalWomensDay #IWD2025 #WomenInLeadership

For the second part of our Women in Leadership series leading up to International Women’s Day, we spoke with Laura Hare, CHARM’s newly promoted Chief Operating Officer! Laura’s leadership and vision are shaping CHARM’s next phase of growth, and she shared her insights on the importance of inclusivity in the workplace along with her advice to young women aspiring to leadership roles.   We are proud to have leaders like Laura driving CHARM forward. Stay tuned for our final leadership spotlight on International Women’s Day!   #InternationalWomensDay #IWD2025 #WomenInLeadership

At CHARM Therapeutics, we believe that strong leadership and innovation go hand in hand. In line with this year’s #InternationalWomensDay theme to #AccelerateAction, we’re proud to have a leadership team that reflects our commitment to diversity, with 50% of our leaders being women who are driving AI-powered drug discovery forward.   As we approach International Women’s Day, we’re celebrating the exceptional women at CHARM who are redefining the future of drug discovery. Over the next week, we’ll be spotlighting our three female leaders, sharing their insights and experiences. To kick off the series, Dr Beverley Carr, Chief Business Officer at CHARM gave us a quick insight into her journey in business development and her advice for women looking to break into the field.   Stay tuned as we continue celebrating the incredible women leading CHARM ahead of International Women’s Day!   #InternationalWomensDay #IWD2025 #WomenInLeadership

CHARM Therapeutics is transforming the future of drug discovery via DragonFold, CHARM’s AI platform that predicts protein-drug binding structures. Watch our CEO Laksh Aithani recount CHARM’s story so far and vision for the future.   #drugdiscovery #deeplearning #AI #cambridge 

Our CEO Laksh Aithani recently sat down with In Vivo’s Jo Shorthouse to talk about how DragonFold, CHARM’s AI platform that predicts protein-drug binding structures, is transforming drug discovery. He discusses our approach to addressing drug resistance, our progress toward clinical trials, and our collaboration with Nobel laureate David Baker.   To read the full article in In Vivo: https://lnkd.in/dZ8UwFJs  

CHARM Therapeutics is #hiring! We are seeking a true HR generalist motivated to take responsibility for the full HR remit as our People Manager. Reporting to Laura Hare, our Chief People Officer, the role offers flexibility and variety, partnering with CHARM's wider team to achieve cutting edge scientific and technological innovation.    Find out more about this position and apply below.