ChromSolutions

Analytical Method Validation Validation of GC and GC/MS methods is critical for ensuring data integrity in various applications, including environmental, forensic, chemical, petrochemical, pharmaceuticals, and food safety testing. To find out the key considerations in the validation process, download ChromSolutions free no obligation reference guide. https://lnkd.in/em_Q89Ct #support #gc #gcms #training #ChromSolutions

  GC & GC/MS Method Development/Optimisation and Objectives Obtaining a separation is one of the simpler parts of the process of method development. There are many other parameters of the chromatographic system that require optimisation and because newer instruments have newer sample preparation techniques incorporated into them, there is an extra dimension to understand and optimise. We are offering a free GC & GC/MS essential guide that gives practical advice which we hope will assist users to understand how the optimisation all aspects of method development that can benefit their organisation. This can range from more accurate results to significant increasing instrument uptime and lower maintenance costs. The objective being to develop automated reliable sample introduction, separation, identification, and quantitative results that are fit for purpose. For a free no obligation GC & GC/MS method development objectives guide. https://lnkd.in/esxYvN_7   Also see our free guide on the method development process. https://lnkd.in/dyQj53T #support #gc #gcms #ChromSolutions

What type of GC or GC/MS do you have? GC’s and GC/MS’s can be vastly different in their configurations & complexity depending on the applications and uses. The general terms used are “regular GC”, “GC analyser”, or “custom solution GC.” It is important to know from an installation, training, servicing and support angle. What type(s) of GC do you have? To find out which type(s) you have download ChromSolutions free no obligation reference guide https://lnkd.in/eVa3PBx3 #support #gc #gcms #training #ChromSolutions

GC Gas Analysis Gases can be analysed by GC very effectively, from ppb levels to 100%. Below is a list of 6 considerations. 1)     The sample vessel and sample state are the first issue that needs to be considered and how this can be introduced into the GC. 2)    There are also fewer columns available that can separate gaseous samples. 99% of columns that are used in this field are based on solid adsorbents, rather than a liquid stationary phase. 3)    In most cases 2 or more columns are used (multidimensional chromatography) which typically involves packed columns, valves, or separate pressure sources to divert the analytes and matrices to the correct path. 4)    Detectors for gas analysis may be used that are not the most commonly heard of (TCD, PFPD, SCD, PDHID) and have their specific limitations and nuances. 5)    Mass spectrometer detectors can be useful for identifying unknowns such as CFC’s, however hydrocarbons can have similar fragmentation patterns and the lower molecular weight gases are not detectable or have a very poor response. 6)    A majority of gas analysis instruments are termed “analysers” or “custom solutions”, that are purchased for a specific purpose. 7)    If the analysis changes the instrument may need to be reconfigured from a hardware point of view, which can be expensive. For a detailed free gas analysis quick reference guide go to https://lnkd.in/d3T3Xx4 #support #training #gc #gcms

GC & GC/MS Relocation Relocating a Gas Chromatograph (GC) or a Gas Chromatograph-Mass Spectrometer (GC/MS) is a meticulous task that requires careful planning and execution to ensure the integrity and functionality of the instrument. If you want to understand more, download our quick reference guide. https://lnkd.in/eiAvTtup #support #training #gc #gcms

GC & GC/MS Training with a Difference Training may seem a simple service to offer, however it takes many years of experience and professionalism to deliver a training course in an interesting and engaging manner. In reality for GC & GC/MS training, most trainees are at completely different levels of ability and experience in relation to aspects of the technique, instruments, software. In addition, certain industries and markets have unique instrument techniques, configurations and applications that require different knowledge that a general GC analyst may have no or at best, limited experience in that area. Therefore, generic training on techniques and software are disjointed and incomplete. What is really required is a bespoke detailed program around your instrument, application /market segment and most importantly the individual(s) on the course. Also, there is a logical optimal scheduled timing and pathway to increase your relative productivity. If you want to get the most of your instrument and software, download our training guide. https://lnkd.in/d_GvYNa #support #training #gc #gcms

Considerations for Changing Carrier Gas GC & GC/MS With the increasing costs and supply chain issues for Helium, customers are increasingly looking for alternative carrier gases for their existing and new analysis, particularly GC/MS For a free fundamental GC & GC/MS quick reference guide go to https://lnkd.in/dUZejXGP #support #training #gc #gcms

Instrument Installation, Hand Over Procedure – Not what it should be? After carrying out extensive evaluation and ordering the correct configuration and software options, you await delivery of your GC/MS! You make sure the lab has the environmental and gas requirements, so you are good to go? However what tests, training program have been agreed with the supplier. In 99% of cases with a GC/MS a sensitivity test (Typically octofluoronapthalene, OFN) is performed and 1 hour of familiarisation training is carried out. However, what about your application and how you acquire, process and report data? The OFN test does not take into account the activity within the sample path and repeatability and tests are not performed, therefore how can you be sure the autosampler, injector, column(s) and detector are performing to specification. If you are unfamiliar with the technique, hardware, and software there is a lot to learn, which should be scheduled in bite sized training slots. In the past this has been impossible to achieve and very expensive. Why not consider a bespoke remote purchasing, support, and training package? For a free GC/MS Installation Hand Over Guide go to https://lnkd.in/d8bb5pn #support #training #gc #gcms

GC & GC/MS Problems – Where do they lie? A fault has occurred, or a result has been queried. Where does the issue lie? Modern instruments are exceptionally reliable however some customised analysers are far more complex now, then they were 20 years ago. They might have integrated extraction devices and customised software. Smaller companies may not have the expertise to diagnose or solve the problem. For a free GC/MS Troubleshooting guide go to https://lnkd.in/d6r9Uwm #support #training #gc #gcms

How far have we come in Gas Chromatography? This post was inspired on a visit to an old client who handed me a book on chromatography published in 1970's. It got me thinking about how long I had been performing GC analysis and back to my first venture into capillary chromatography in 1978 as a project in the 1978 in the ICI research site at Runcorn. Admittedly the chromatogram is circa 1981 and using fused silica capillary columns, rather than glass (now they were tricky to install!). However, chromatogram shows a 1ul injection of a standard using on-column injection and fused silica needle. The hydrocarbons were being used to identify a possible internal standard candidates. Challenges back then: 1)     Picking up a sample from a volumetric flask with a syringe with a fused silica needle (0.25 mm o.d.) then inserting on-column injector without air gaps or breaking the needle was no mean achievement. 2)    Keeping peaks on scales for quantitation (attenuators used). 3)    Not even integrators back then, never mind PC’s. 4)    Peak identification - Overlaying feature (putting the standard and reference chromatogram against a window). 5)    Manually calculating each components peak height and comparing with a standard to calculate the concentration. Well today we can automatically inject and process 50-500 samples a day using GC/MS/MS, GC*GC or instruments configured multi-injector/valve, columns, detectors. Samples can be prepared on the autosamplers (SPE, SPME, centrifuged, Etc). New techniques and detectors such as SPME PFPD have been invented. Data can be automatically reported and exported into custom formats for Calculations or LIMS packages. Chemometrics can be used to identify sample patterns and clusters for differences and adulterations. It has been amazing to be involved in that change and offer bespoke analytical solutions to organisations without the experience and skillsets required. Not matter where you are on your analytical journey search Chromsolutions website for free no obligation guides. https://lnkd.in/drYVzH3 #support #gc #gcms