Constructive Bio

💡 Biology has been stuck with 20 amino acids for billions of years. If we truly want a bio revolution, should we rethink this? This week, Ola (Aleksandra) Wlodek will be speaking at the Milner Seminar about a fascinating idea: 🔹 What if we could go beyond nature and build proteins from hundreds of new amino acids? 🔹 What if we could program biology to carry out functions nature never imagined? At Constructive Bio, we’re doing exactly that—engineering entirely new chemistries into proteins, with potential applications in therapeutics, biomaterials, and beyond. This shift could rewrite the rules of life—but what boundaries should we push first in creating new-to-nature functionalities?? Would love to hear your thoughts! Let’s discuss. 👇 #ProgrammableBiology #BiotechInnovation #AminoAcids #MilnerSeminars

We're #hiring a new Research Associate – Synthetic Genomics in Cambridgeshire, England. Apply today or share this post with your network.

Thanks for highlighting our efforts here, led by Faye Rodgers and Daniel de la Torre!

🔔 Innovate UK Grant Success 🔔 We are excited to share that we have been awarded Innovate UK funding to help transform the way the pharmaceutical industry manufactures therapeutic peptides. We’ve been awarded this funding as part of the Sustainable Medicines Manufacturing Innovation: Collaborative R&D competition.    Peptides are a fast-growing and hugely impactful class of therapeutics that includes blockbuster GLP-1 agonists like semaglutide (Ozempic/Wegovy) and Tirzepatide (Mounjaro/Zepbound). However, it’s estimated that 13 tonnes of waste are produced on average for every kilogram of peptide using conventional chemical synthesis methods.   In this £1.1 million initiative, we will partner with scale-up experts at CPI to demonstrate the potential of an alternative biomanufacturing route at pilot scale. Together we aim to reduce the industry’s reliance on harmful solvents and lay the foundations for scalable production of the future of high-impact drugs.   We can’t wait to get started! #Sustainability #MedicinesManufacturing #SMMIP #InnovateUK 

We're #hiring a new Laboratory Technician in Cambridgeshire, England. Apply today or share this post with your network.

Why do we use the same 20 amino acids to make synthetic proteins? 🔬 I am glad you asked! Constructive Bio is using non-canonical amino acids to create polymers that we have not come across before. It sounds complex, but it might be surprisingle simple. Imagine having to use the same 26 letters to make words. Each word, serves a specific purpose, it communicates a specific thing. But all of a sudden, you cannot say what you need to say! You realise adding a few extra letters, stealing inspo from the Nordics, maybe you come across a: ä or a ë This allows you to create a new word, that means exactly what you want to say. This is in a nutshell how our genes make proteins. They encode for 20 amino acids (letters), we mix and match them to make 1000s of different proteins (words) and these words are powerful... We need proteins for structure (like the keratin in your hair), or to carry things (like the heamoglobin carrying oxygen in your blood), but we also need proteins to signal things (like the GLP-1 in your stomach that signals you are full to your brain)! Creating proteins de-novo could allow us to create new drugs but also could allow us to turn cells into little green factories 🧫 , making proteins that we can use as alternative materials! Meet the founders and team behind this incredible company: Ola (Aleksandra) Wlodek, Prof Jason Chin, Faye Rodgers, Andre Pulschen, Dionysis Grigoriadis, Tomás Kappes Reveco, PhD, Bill Eldridge and more. #biotech #techbio #proteins #syntheticbio #deeptech #startup #advancedmaterials

We're #hiring a new Laboratory Technician in Cambridgeshire, England. Apply today or share this post with your network.

Our CSO and founder, Jason Chin, is not just writing genomes—he's writing the future as a founding director of the ambitious Generative Biology Institute!

🚀 We’ve been shortlisted! 🚀 Excited to share that Constructive Bio has been shortlisted for the One Nucleus Awards 2025 in the R&D Platform Development Company category! 🎉 A huge thank you to Tony Jones and One Nucleus and the judges for this recognition. Congratulations to other platform finalists— Nuclera and OutSee (whom we are sharing investors with!) —excited to celebrate with you on March 27! Our team at Constructive Bio is pioneering the future of synthetic genomics and engineered translation, and this nomination fuels our drive even more. Let’s make biology work for us! 💡🧬 https://lnkd.in/enWvFGXa #OneNucleus #Biotech #SyntheticGenomics #ConstructiveBio