Division of Molecular and Cellular Function, University of Manchester

MRC-funded PhD available in Ximena Soto group. Apply, ff you are enthusiastic and keen on using Zebrafish to elucidate signals and mechanisms involved in spinal cord regeneration apply! more information below: https://lnkd.in/ePWwPJac

📢 Are you a clinician looking to undertake a PhD in cancer cell biology research? We have a Clinical Research Training Fellowship opportunity with the Manchester Cancer Research Centre and the Cancer Research UK Manchester Centre! This exciting project will use advanced cell culture models and 'omics technologies to understand how lung cancer cells respond to changes in their microenvironment, seeking to develop new ways to detect lung cancer earlier. 🔗 For details on the project, and how to apply, click here: https://lnkd.in/ePdxqWTa ⏰ The closing date for applications is 15th November 2024 Please get in touch (https://lnkd.in/e8Ry524c) if you are interested in joining us in the lab and working with the fantastic team (including Sean Knight, Sarah Cartmell, Phil Crosbie) across the Division of Molecular and Cellular Function, University of Manchester, the Division of Infection, Immunity and Respiratory Medicine, the Lydia Becker Institute of Immunology and Inflammation, and the Henry Royce Institute #postgrad #medicine #research

Two exciting PhD opportunities with Adam Byron lab: If you a clinician looking to undertake a PhD in cancer cell biology research the Byron Lab have a Clinical Research Training Fellowship opportunity with Manchester Cancer Research Centre.  Details:  https://lnkd.in/ev7hk5KY or If you are interested in doing a PhD in cancer cell biology the Byron Lab have a fully funded MRC DTP studentship: For details on the project, and how to apply, click here:  https://lnkd.in/ewx3BtHC

Dr Kerrie Marie, Dr Rebecca Lee and Dr Adam Hurlstone are recruiting PhD candidates to an exciting project uncovering, “The role of phosphatases in melanoma metastasis and therapy resistance”.   This is a collaborative project that focuses on preclinical, translatable science and mechanistic studies and has strong ties to the clinic.  Please follow the link below if you want to learn more.   https://lnkd.in/eQa3tten

PhD postions open in Sankari Nagarajan lab:

Our division has strengthened ties with industry. A research group led by Pawel Grzechnik (MCF, University of Manchester) will collaborate with the RNAHub (Roche Pharma Research and Early Development) as part of the Roche Access to Distinguished Scientists Programme. We are joining forces to investigate the impact of antisense oligonucleotides on RNA synthesis in human cells. @ The University of Manchester Faculty of Biology, Medicine and Health

Non covalent spin labelling enables EPR distance measurements for studying dynamics on the human tetrameric TRPC5 ion channel. With 84 x native Cysteines, TRPC5 is not accessible by conventional Cys- spin labelling methods. CryoEM structures of TRPC5 with spin labelled activator and inhibitor confirm DEER findings. Our study could pave the way for monitoring conformational/ oligomeric ensembles and asymmetries in TRPC5 and potentially other human TRP channels by EPR (DEER / PELDOR). Great effort by Robin Bon Lab & members of our group Anokhi Shah, Mary Ma, Josh Wort, Andrew Wilson lab & Stephen Muench lab MCF University of Manchester Manchester Institute of Biotechnology The University of Manchester Faculty of Biology, Medicine and Health

We are back after the summer break! We have some exciting news from our Division: new starters, papers, and grants. Stay tuned! Let's start with our regular series: Meet the team: Dr Christos Pliotas Pilotas lab investigates the molecular basis of mechanosensation and its role in the regulation of ion channels using Electron Paramagnetic Resonance (EPR) spectroscopy, Pulsed ELectron-electron DOuble Resonance (PELDOR), also known as Double Electron-Electron Resonance (DEER) spectroscopy and Cryo Electron Microscopy (cryoEM). They functionally characterise these systems by employing single molecule electrophysiology methods. Lear more about research in the Pliotas lab: https://lnkd.in/evfby8pP https://lnkd.in/evfNSnXc

Team effort to characterise membrane-bound pyrophosphatases (mPPases), promising drug targets for treating diseases caused by parasitic protists. 

Research Technician position available in Ximena Soto lab! Join them and help them assess the functional importance of dynamic gene expression underlying spinal cord regeneration! https://lnkd.in/dp2GygGX