Earlham Institute

📣 Applications are now open worldwide for the NRPDTP Doctoral Training Partnership, we have 7 unique and exciting PhD projects available for Oct 2025 start. Take a look below at the projects and apply via our website before 25 November 2024: Dr Edyta Wojtowicz #molecularbiology 🩸 Decoding blood formation: exploring the hidden pathways from stem cells to platelets 🥬 Exploring how low-protein diets reshape immune responses to pathogens Dr Conrad Nieduszynski #dnareplication  🔁 Cellular response to DNA replication stress 🧬 Engineering stable designer chromosomes Dr Iain Macaulay #singlecellgenomics 🔎 Single-cell CSI: single-cell sequencing for DNA evidence recovery Dr Wilfried Haerty #cellulargenomics 🧬 The message in the noise: characterisation and quantification of noise in alternate splicing Prof Anthony Hall #wheatgenetics 🌾 Exploring how RNA splicing influences the transcriptional landscape of wheat To find out more about the projects available, our group leaders, and PhD life at the Earlham Institute, head to our website 👇 ➡ https://lnkd.in/edJZmzqf #PhDProject #Postgraduate #FindaPhD #PhDopportunity #Biosciences #LifeSciences #Genomics #Bioinformatics #ResearchInstitute

𝗛𝗼𝘄 𝘁𝗼 𝘂𝘀𝗲 𝘀𝗽𝗮𝘁𝗶𝗮𝗹 𝘁𝗿𝗮𝗻𝘀𝗰𝗿𝗶𝗽𝘁𝗼𝗺𝗶𝗰𝘀 𝘁𝗼 𝘃𝗶𝗲𝘄 𝘀𝗶𝗻𝗴𝗹𝗲 𝗽𝗹𝗮𝗻𝘁 𝗰𝗲𝗹𝗹𝘀 𝗶𝗻 𝘀𝗶𝘁𝘂 Spatial transcriptomics is powerful tool enabling scientists to map the location of gene activity in tissue samples. In 2023 the Earlham Institute was the first site in the UK to obtain the Vizgen MERSCOPE platform, and has since gone on to develop methods for difficult sample types. Ashleigh Lister is a Senior Research Assistant in the Macaulay group. She has pioneered the development of these techniques for plant tissues. "Historically, sequencing #singlecells requires their original tissue to be dissociated allowing us to isolate them individually. Although we can learn a lot from this type of sequencing, this dissociation and mixing up can have many disadvantages. A big one is that it confuses the overall picture, or story, of what is happening in that tissue, and therefore that organism. "The technique of spatial transcriptomics means the cells are left in situ, undisturbed in their natural positions, alongside their neighbours." In a new technical article, Ashleigh shares her first-hand experience of the workflow, some top tips, and methods for using this technology to view single plant cells in situ. https://okt.to/OcbuiK Thanks go to BBSRC for providing funding for the platform and supporting the research Ashleigh contributes to.

📣 Fully-funded #PhD: Exploring how RNA splicing influences the transcriptional landscape of wheat. Wheat has immense global importance and researchers are constantly engaged in identifying genetic variation to increase yield, resilience, and disease resistance. Working with Prof Anthony Hall this project will: 🔎 explore how RNA splicing impacts the transcriptional landscape 🧬 apply cutting-edge sequencing and computational approaches 🌱 collaborate with leading wheat breeders for applications in agriculture 💻 use machine learning to predict alternative splicing 📍 Norwich, UK 🗓️ Apply by: 23.59 on Monday 25 November 2024 🗓️ Start date: October 2025 https://okt.to/swNrCO NRPDTP Doctoral Training Partnership

📣 Fully-funded #PhD: Decoding blood formation: exploring the hidden pathways from stem cells to #platelets. 🩸 Blood clotting is an essential response to injury and is crucial for survival. Platelets are the cells responsible and need to be produced at an astonishing rate of 1 trillion per hour to maintain this function. Failure to do so can be life threatening and is a frequent issue in the elderly, cancer patients, and people with autoimmune diseases. Using cutting-edge #singlecell and #bioinformatic techniques, this project will investigate the molecular differences between stem cells that produce high and low numbers of platelets. 📍 Norwich, UK 🗓️ Apply by: 23.59 on Monday 25 November 2024 🗓️ Start date: October 2025 https://okt.to/9DutSZ NRPDTP Doctoral Training Partnership

Next month, Senior Research Assistant Ashleigh Lister will be joining Agri-TechE for #REAP2024. Ashleigh will be speaking as part of the Emerging #AgriTech session, on her experience using sequencing and spatial technologies to better understand the genetics of wheat pollen and spikes. The Agri-Tech session provides the agricultural and research community an opportunity to share and discuss research and real-world applications. https://okt.to/BdN9u1

📣 Join us next month for the inaugural Dame Janet Thornton Lecture. The lecture recognises Prof Thornton's distinguished career, and her significant contribution to broadening the scope of traditional #bioscience through computational methods. This year we'll be welcoming Elinor K. Karlsson as our speaker, sharing her work with the #ZoonomiaProject, exploring 100 Million Years of evolution for health and conservation. Elinor is a Professor in Genomics and Computational Biology at the UMass Chan Medical School, and Director of Vertebrate Genomics at the Broad Institute of MIT and Harvard. Her research combines genomics, new technology and community science to investigate diseases and discover the origins of exceptional mammalian trails like hibernation and exceptional longevity. Find out more below. https://okt.to/DVvn6m

📣 Fully-funded #PhD: Characterisation and quantification of noise in #alternativesplicing. 🧬 Alternative Splicing (AS) is the process by which different transcripts are generated from a single gene. Understanding AS diversity in cells at steady state and during differentiation can offer new perspectives on the regulation of this essential process. This project will work with Dr Wilfried Haerty at the Earlham Institute, and in close collaboration with scientists at the University of Oxford and Wellcome Sanger Institute. 📍 Norwich, UK 🗓️ Apply by: 23.59 on Monday 25 November 2024 🗓️ Start date: October 2025 https://okt.to/YChmL7 NRPDTP Doctoral Training Partnership

As part of our series of technical blogs from Earlham Institute scientists, Postdoctoral Researcher, Dr Anna Rogers, shares an in-depth guide to using modular cloning systems #MoClo and other plasmid kits to design Golden Gate assemblies for transformation into yeast. 🧬 This first article will walk you through engineering your healing fragment for yeast transformation. In part two, you'll design the custom guide, and the final article will run through the yeast transformation with the system you've built. https://okt.to/8Fx05p #Synbio #MoClo #yeastgenetics #BuddingYeast #HowTo

📣 Fully-funded #PhD: Engineering stable designer chromosomes 🧬 Recent technological advances enable us to write and build whole chromosomes, allowing unprecedented potential for the design and creation of cellular machines. Working with Dr Conrad Nieduszynski and Dr Carolina Grandellis, this PhD will test the design principles for stable maintenance of fully synthetic chromosomes within eukaryotic cells. You will gain a unique expertise in engineering biology, technology development, and automation. 📍 Norwich, UK 🗓️ Apply by: 23.59 on Monday 25 November 2024 🗓️ Start date: October 2025 https://okt.to/mOJiG9 NRPDTP Doctoral Training Partnership

Each year, the Earlham Institute invites two undergraduate students to participate in our #YearinIndustry programme. For some, it will provide valuable experience for their future #careers - with former students going on to become research assistants, software engineers, and biotechnology engineers. For others, it kindles a love of research and sets them on the path to pursue a #PhD. In our latest article, we spoke to two former students who returned to the Earlham Institute for their PhD research. https://okt.to/wZdX6j ⏰ Year in Industry applications are currently open until October 31: https://okt.to/uPXS7e