Kavli Institute for Nanoscience Discovery, University of Oxford

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Had the amazing opportunity to attend the 2024 British Biophysical Society Biennial Meeting #BBS2024 this week at Swansea University! It was a valuable experience to deliver a talk on my research exploring host-pathogen interactions by dynamic mass photometry and to engage such a brilliant community of scientists in the biophysics field. This event highlighted the latest innovations and challenges in biophysics, and I am grateful to have been part of such enriching discussions. Many thanks to my supervisor Weston Struwe, teammates and collaborators for their valuable support and contributions to this work. Also, thanks to the organizers and everyone who attended for their support and inspiring conservation! The warm Welsh hospitality made the experience even more memorable!

It's our great pleasure to introduce Maite Lopez from Kevin Talbot's group this week. Maite is a research assistant investigating disease mechanisms in motor neurone disease using iPSC-derived models. She works primarily on a project for the UK MND Research Institute (UK MND RI). #MND is a complex and fatal neurodegenerative disease for which there is currently no cure. Maite's research focuses on using iPSC-derived motor #neuron and motor neuron-microglia coculture models of the disease to investigate underlying mechanisms and potential therapeutic targets. The techniques she uses include qPCR, immunofluorescence, and #cell assays.

We've always funded interdisciplinary research, through strategic and challenge-led schemes, and through council-specific responsive mode schemes. But what if you've got a great idea for a project, but you don't really see which council you should approach? That's where our new cross council responsive mode scheme comes in. Round two is now open: https://lnkd.in/ePwNdRB2 Tips on how to apply: https://lnkd.in/eU3pqBB7

#TuesdayReads: Weston Struwe Group explores immune responses to β-lactam #antibiotics like Penicillin G. Findings reveal antibody mechanisms driving specificity and suggest future strategies to reduce unwanted immune reactions. #Immunology #KavliOxford The Department of Biochemistry, University of Oxford

Thank you Dr. Brent Ryan in having me to speak in the Kavli Institute at the the University of Oxford on ageing and dementia! Thank you Prof. Khan and @ProfSarahHarper in having me to visit the Oxford Population Ageing Centre!

#TuesdayReads New from Becky Carlyle Group: The PEGASUS trial shows PB & TURSO may reduce key Alzheimer's biomarkers like tau and neurodegeneration proteins, despite no clinical outcome differences. #AlzheimersResearch #Neuroscience Department of Physiology, Anatomy & Genetics - University of Oxford

#MeetTheResearcher Happy to introduce you Emily Carroll this week. Emily is a postdoctoral researcher in Wade-Martins Lab, working on gene therapy approaches for Parkinson’s disease. In her current research, Emily will use high-capacity DNA viral vector expression systems to deliver wild-type versions of familial Parkinson’s disease genes to patient iPSC-derived dopamine neurons. Using a variety of different cellular and molecular biology techniques, Emily will then investigate whether delivery of these genes can rescue dysfunctional phenotypes in dopamine neurons.    Prior to joining the Wade-Martins Lab, Emily completed her DPhil in the Talbot group, where her research utilised cellular assays and microscopy to phenotypically characterise a mouse stem cell-derived motor neuron (mESC-MN) model of amyotrophic lateral sclerosis (ALS). She then explored the value of this model as a platform for phenotypic drug discovery. In her current role, Emily will develop new skills in the development of #DNA plasmid vectors for gene therapy whilst using her previous experience in cellular biology and assay development for the later stages of the project. #Parkinsons #ALS #MotorNeuroneDisease

#TuesdayReads Carol Robinson Group shares a new protocol using native #MassSpectrometry and #Lipidomics to uncover lipid-protein interactions in mammalian membranes. Explore the insights here 👇 Oxford Chemistry #KavliOxford

#TuesdayReads: Stuart Peirson Group's latest paper highlights the need for species-specific light measurement in research settings. It offers practical guidance on appropriate lighting for visual and circadian functions, building on a recent Consensus View. Nuffield Department of Clinical Neurosciences, University of Oxford #KavliOxford #Chronobiology