Newcells Biotech Ltd

🚨In vitro model predicts antibiotics toxicity in vivo 🔎 This paper investigates whether the nephrotoxic responses to antibiotics assessed in vitro correlate with preclinical animal studies. This has a significant impact for the industry, with the results suggesting that VRP-034, an alternative formulation to Polymixin B, an antibiotic with significant nephrotoxicity, may be better tolerated in vivo in humans due to reduced sensitivity. Find out how to read the full paper 👉 https://lnkd.in/eNMGhYkv #Newcells #Antibiotics #AKI #InVivo #2025SOT #Toxicity

The final day of Society of Toxicology (SOT) is underway in Orlando! ☀️ We've had some great conversations so far with Clive Roper BSc PhD CBiol CSci ERT FRSB, Craig Llewellyn and many other leading industry experts 💡 👋 You can find us at Booth #1248 to learn more about our models. #Newcells #2025SOT #Toxicology #DrugDevelopment

🚨 EXPERT Insight: Dr Valeria Chichagova, PhD, Director of Technology at Newcells, discusses the latest trends and the potential for in vitro models to replace animal testing. She explored the following, what are your thoughts? ✔️readiness of in vitro models to replace or complement in vivo models ✔️whether can in vitro models provide similar information as in vivo models? ✔️data collaboration between industry, academia and therapy developers ✔️AI and in Silico models for advanced complex models ✔️harnessing the predictive data of in vitro models ✔️innovation and collaboration between customers, regulators and innovators Listen to the full interview here ⏯ https://lnkd.in/eSYKVUrX #Newcells #InVitroModels #DrugDiscovery #PredictiveModels #Innovation #BioTech

📍This week our team are at the annual Society of Toxicology (SOT) meeting in Orlando to discuss our toxicity services 👋 ⚠️ Drug-induced nephrotoxicity is one of the leading causes of drug failure, with 2% attrition in pre-clinical and 19% attrition in phase 3. Early detection of in vitro nephrotoxicity is key to reducing both costs and timelines 💸⏱ 🔬Our aProximate™ proximal tubule cell model assesses renal toxicity with unparalleled accuracy, enabling detection of early and late toxic effects. This model fulfills a critical need in nephrotoxicity assessment, providing essential data to improve drug safety profiles. Find out more about improving your drug safety assessments 👉 https://lnkd.in/esk-H_sc #NewcellsBiotech #Nephrotoxicity #DrugSafety #InVitroModels #PreclinicalResearch #Toxicology #2025SOT Catherine Ulich

What's your goal? 🎯 At Newcells, we're on a mission to revolutionize kidney research with our cutting-edge in vitro proximal tubule cell model 🧪 💡 What sets us apart? ✅ High expression of key renal transporters like megalin and cubilin ✅ Rigorous protocols for reproducible, predictive data ✅ Tailored assay packages to accelerate drug discovery ✅ Model appropriate to test both small and large molecules We’re proud to collaborate with leading pharmaceutical and biotech companies, supporting IND submissions with nephrotoxicity assays, disease models, and more. Our ultimate goal? To make kidney disease models even more clinically relevant and impactful 🌟 🔬 Lets push the boundaries of kidney research together! Learn more or reach out to explore how we can help accelerate your breakthroughs. https://lnkd.in/eWmfv5hS #KidneyResearch #BiotechInnovation #DrugDiscovery #PharmaceuticalScience

All set up and ready to go at Society of Toxicology (SOT) 2025 in Orlando!📍 👋 Stop by Booth #1248 to say hi and learn more about our models. #Newcells #2025SOT #Toxicology #DrugDevelopment

📊 15–20% of all Stargardt disease (STGD1) cases remain unsolved with just one of the two, or no pathogenic ABCA4 allele variants identified, despite a strong clinical indication of the inherited disease. 💡Key facts: 🔹 This publication presents the first demonstration of STGD1 ROs exhibiting a phenotypic defect characterised by photoreceptor mislocalisation, which correlates in intensity with disease severity. 🔹The STGD1 ROs displayed gene dysregulation in stress-response and phototransduction pathways, indicating that the model can recapitulate STGD1 phenotypes in vitro. 🔹The model allowed for genetic resolution of previously monoallelic cases. 🧑🔬 The team generated induced pluripotent stem cells (iPSCs) from two monoallelic late-onset STGD1 cases and differentiated them into retinal organoids (ROs) alongside affected and unaffected control iPSCs 👁️ 📑 Read the full paper now 👇 #Newcells #StargardtDisease #InVitroModels #RareDisease #RetinalDisease EPSRC Lyle Armstrong Valeria Chichagova, PhD Ana Conesa Majlinda Lako Darin Zerti Michael M. Jonathan Coxhead Rafiqul Hussain Joe Collin Rachel Queen Avril Watson, PhD

💬 “We're passionate about making sure that we not only know what our customers need today, but importantly what they need for the future so we can continue to strive to innovate, to come up with better models than we currently have.” 🌟 Our unique value lies in the three platforms that we use - retina, kidney and lung - all based on the same biology. We start with simplified models to provide core data, and build more complex models as needed for advanced drug development. By working closely with our customers, we ensure our complex models can critically answer their specific questions. 🔬Working in one of the highest spending R&D sectors globally, we stay ahead in terms of innovation, imagination, delivering data and solutions that meet our customers’ evolving needs. Discover what Newcells brings to the table👇 #Newcells #InVitroModels #DrugDiscovery #DiseaseModelling #TissueEngineering

⏰ We're counting down the days until the 64th annual meeting of the Society of Toxicology (SOT) in Orlando! ☀️ 👋 Our team will be on-site at Booth #1248. Stop by to say hi and learn all about our models and latest innovations💡 🧑🔬Catherine Ulich, Colin Brown, Adam Pearson #Newcells #Toxicology #SOTAnnualMeeting #2025SOT

🗓 Today marks #WorldKidneyDay - raising awareness of the importance of our kidneys! Is it possible to confidently decide which animal model will provide the most relevant renal toxicity data to then progress to regulatory submission for human studies❓ 🔬 In this study, we investigated pharmacodynamic discrepancies that our client had observed in vivo between rat and dog when dosed wtih an active ingredient and provided supportive data for their submission. 🔎 Case Study: In vitro selection of the most relevant species to predict human renal toxicity: https://lnkd.in/exaSp-by Learn more about World Kidney Day here: https://lnkd.in/fW-T8xB #Newcells #DrugDevelopment #RetinaModels #AnimalTesting #AKI #2025SOT #SOTAnnualMeeting #Toxicology