Pharmig microbiology

Pharmig podcast: David Keen on the contamination control strategy. Tim Sandle interviews David Keen (Ecolab and Pharmig Chair) about cleaning, disinfection and contamination control: https://lnkd.in/ejvuFUN5

Scientists have shown that by heating up small nanorods of gold with near-infrared light (NIR), bacteria are killed, and the surface of the implant becomes decontaminated. Read more: https://lnkd.in/eknhcyWM

Tim Sandle looks at how air control helps to maintain a cleanroom in a good state - contamination control in action! https://lnkd.in/e63DfK2i

This week’s article looks at the bacterium and also highlights some new research that charts how the organism evolved rapidly and then proceeded to spread globally over the last 200 years. At the heart of this are changes in human behavior. See: https://lnkd.in/ef2XcpMr

Some bacteria are able to shed their cell wall assume new, mostly spherical shapes. These are known as L-forms. These bacteria not only differ by shape; they also differ fundamentally from normal forms of bacteria. The stress response mechanism of bacteria helps the formation of L-form bacteria. This week's article assesses the L-form bacterium phenomena and considers what this form means for two key areas: antimicrobials and sterile filtration. See: https://lnkd.in/eMfKaFYC

Chlorination can be applied to mains water and initial stages of water generation, for pharmaceuticals. In addition, chlorination is an important step for ensuring public drinking water and shared services, like swimming pools, remain suitable for human use. This week’s article looks specifically at chlorine and its use as an antimicrobial agent in a water system: https://lnkd.in/eipv-pn7

Improving aseptic transfer: Advantages of the IsoBag® solution. A potential microbial contamination transfer risk exists with both RABS (restricted access barrier systems) and isolators, given the need to introduce materials from outside of the protective barrtier. While isolators afford greater protection by virtue of providing a complete barrier and an environment that can be subjected to an automated decontamination cycle, the transfer issue still presents a concern. This article looks at the problem of transferring materials to the aseptic core from lower controlled environments and describe a solution from Merck that significantly improves the environmental monitoring workflow through the use of the IsoBag® solution: https://lnkd.in/essKhE3K

Sandle on rapid microbiological methods https://lnkd.in/egzxsc2r #microbiology#pharmaceuticals

Enhanced Risk? EMA Issues New Guidance For OSD Co-processed Excipients   Many pharmaceutical products contain excipients: inactive substances acting as a medium for a drug product. In recent years there has been a drive toward the use of co-processed excipients to aid leaner manufacturing. This has prompted the European Medicines Agency (EMA) to develop a new guidance document titled “Questions and Answers regarding co-processed excipients used in solid oral dosage forms (H & V).” Here is a review of the key points: https://lnkd.in/efjvp4_c

In this week’s article, I take a look at dust and microorganisms and what we can learn from aerobiology and the aerobiome. Find out more here: https://lnkd.in/eTupi9gz