The Lancet Group

🆕 Once-a-year injection to protect against HIV is safe and shows promise as a long-acting prevention medication, phase 1 study finds. The latest study, presented at the 2025 Conference on Retroviruses and Opportunistic Infections (CROI), is the first to evaluate a once-yearly injection of an HIV pre-exposure prophylaxis (PrEP) medication. Expanding the options for PrEP can help overcome current barriers to access and adherence, and drive progress toward reducing new HIV infections. Find out more ▶️ https://hubs.li/Q03bG_nG0 👇 Figure: Median (IQR) plasma concentration–time profiles of once-yearly intramuscular lenacapavir versus twice-yearly subcutaneous lenacapavir for formulation 1 (A) and formulation 2 (B).

✨ Exciting new Lancet role ✨ This autumn, we will launch an open-access journal dedicated to the unique health challenges on the African continent: The Lancet Regional Health—Africa. To support this important endeavour, we are searching for a Senior Editor—someone who can ✅ Manage the creation and publication of original, engaging material ✅ Oversee submissions and quality peer review to ensure we publish high-quality content ✅ Build global relationships with experts in the community This will be a full-time, in-house position, based in Cape Town, South Africa. Think you or someone you know is the ideal candidate? Find out more and apply here ⤵️ https://hubs.li/Q0398Ndh0

🆕 “More than half of adults and a third of children and adolescents predicted to have overweight or obesity by 2050” Without urgent policy reform and action, over half the world’s adult population (3.8 billion) and 1/3 of all children and adolescents (746 million) are forecast to be living with overweight or obesity by 2050. This poses an unparalleled threat of premature disease, according to a major new analysis published in The Lancet. “Ultimately, as global obesity rates continue to soar, much stronger political commitment is needed to transform diets within sustainable global food systems and to support comprehensive strategies that improve people’s nutrition, physical activity and living environments, whether it's too much processed food or not enough parks”, said author Dr Kerr. Find out more in these articles ⤵️ 1️⃣ hubs.li/Q039bPS-0 2️⃣ hubs.li/Q039c0tk0 Figure from paper 1: Estimated age-standardised prevalence of obesity in adults aged 25 years and older by sex, globally and by super-region, 1990–2050. (A) Females. (B) Males. (C) All sexes combined. Shaded regions are 95% uncertainty intervals. #WorldObesityDay

✨ Exciting new Lancet role ✨ This autumn, we will launch an open-access journal dedicated to the unique health challenges on the African continent: The Lancet Regional Health—Africa. To lead this important endeavour, we are searching for an Editor-in-Chief—someone with a good understanding of ✅ The challenges facing health care across Africa ✅ The dependencies and nuances within and between countries ✅ A well-established network of colleagues established during their time working in medicine or medical research The Editor-in-Chief will ensure all content meets the rigorous standards of external peer review and that expected by our readers. This will be a full-time, in-house position, based in Cape Town, South Africa. Think you or someone you know is the ideal candidate? Find out more and apply here ➡️ https://hubs.li/Q038Lk5B0

🆕 Since the WHO declared the Zika virus epidemic a public health emergency in 2016, there are still no licensed vaccines, treatments, or routine diagnostic tests. This leaves the world vulnerable to future outbreaks ❌ As a result, experts created a priority agenda for Zika virus research and development, based on extensive reviews and input from 125 global thought leaders. A joint Lancet Infectious Diseases–Lancet Microbe Series summarises ✅ The current science ✅ Key research challenges ✅ A strategy to advance research, surveillance, global capacity, policy, and investment for Zika virus preparedness and response "Overcoming complacency and building investment...will be essential for global preparedness and response against future epidemics", say authors. Find out more ➡️ https://hubs.li/Q038L9nf0 -- Alt text: Three graphic cards in pastel orange, blue, and green show illustrations of infection pathways for Zika virus, the virus' effects, and actions to advance research and development. For more information, read the Series in full. The Lancet Infectious Diseases

🆕 Since the WHO declared the Zika virus epidemic a public health emergency in 2016, there are still no licensed vaccines, treatments, or routine diagnostic tests. This leaves the world vulnerable to future outbreaks ❌ As a result, experts created a priority agenda for Zika virus research and development, based on extensive reviews and input from 125 global thought leaders. A joint Lancet Infectious Diseases–Lancet Microbe Series summarises ✅ The current science ✅ Key research challenges ✅ A strategy to advance research, surveillance, global capacity, policy, and investment for Zika virus preparedness and response "Overcoming complacency and building investment...will be essential for global preparedness and response against future epidemics", say authors. Find out more ➡️ https://hubs.li/Q038L9nf0 -- Alt text: Three graphic cards in pastel orange, blue, and green show illustrations of infection pathways for Zika virus, the virus' effects, and actions to advance research and development. For more information, read the Series in full. The Lancet Infectious Diseases

Life expectancy improvements slowed or declined in many European countries from 2011-2021, suggests the latest Global Burden of Disease study. 📉 During the COVID-19 pandemic (2019–2021) several European countries experienced a decline in life expectancy, with Greece and England experiencing the largest decrease. The findings highlight the need for stronger government policies to address obesity, improve physical activity, and increase access to health care to improve population health. Explore the latest data: https://hubs.li/Q037xq7v0 🔽 Figure: Changes in life expectancy at birth for both sexes combined, by country and cause of death from 1990 to 2011, ordered by 2019 life expectancy. Institute for Health Metrics and Evaluation.

Most of us are affected by cancer in some way during our lifetime. Over the past two decades, substantial advancements in cancer research and treatments have been made, leading to improved survival rates for cancer patients. “The impact of [cancer] in society means that there's a need to focus and to do more research, so that we can hopefully prevent the disease instead of treating [it]”, says Vania Wisdom, Senior Executive Editor, The Lancet. At The Lancet Group, our editors are dedicated to publishing the latest research that will advance treatment and care and have a real impact on the people affected most. From innovative treatments to improving access to care globally, find out more on the importance of oncology research and how it is shaping the future of cancer care: https://hubs.li/Q037mGkC0 Alt: Trailer for The Lancet Group video “Advancing Cancer Care and Research Together”

60% of the world lacks access to safe, affordable medical oxygen. ❌ This results in preventable deaths and overwhelmed health systems during crises. Medical oxygen is a highly cost-effective investment to advance public health globally. A new Commission report outlines 52 recommendations to close coverage gaps. Read in The Lancet Global Health 👉 hubs.li/Q0374_FC0 Figure: Location of people with acute medical and surgical oxygen needs in 2021, and minimum volume of oxygen required to meet need, by World Bank region

As a new destination for open access research in #primarycare, we believe in the power of quality primary care, considering the psychological, social, and economic dimensions of health, to reduce social inequities and reach all at-risk populations, including children and adolescents, older people, women, and other minoritised or underserved communities. We hope to serve as an independent platform for the community to discuss the most pressing issues affecting its workforce, clinical decision making, healthcare delivery models, and patient and provider experience, and facilitate alliances between health-care professionals, the public, and policy makers to shape the future of primary care. Read our full aims and scope and discover more here ➡️  http://bit.ly/4b2a9W3  #primaryhealthcare #familymedicine #internalmedicine