The Lancet

Fractures affect a substantial proportion of people with obesity, constituting a considerable public health burden. There are several reasons for this, including adverse effects of adipose tissue on bone and muscle and, in many people, the coexistence of type 2 diabetes. Although weight loss in people with obesity has many health benefits, it can also have adverse skeletal effects, with increased bone loss and fracture risk. With obesity nearly tripling over the past 50 years, "[p]riorities for future research include the development of effective approaches to reduce fracture risk in people with obesity and the investigation of the effects of GLP-1 receptor agonists on bone loss resulting from weight reduction", say authors in The Lancet Diabetes & Endocrinology. Find out more in a Review: https://hubs.li/Q02HMLkz0 ⬇️ Figure: Pathogenesis of fractures associated with obesity

“A profit-driven fertility industry cannot continue to prey on the vulnerabilities of people who desperately hope to have children.” The Lancet’s latest Editorial: https://hubs.li/Q02HcCBg0

“If we give health-harming industries the freedom to sell whatever they like to whomever they like at whatever price they like, then we will have to deal with the dire consequences for public health.” The tobacco, ultra-processed food, fossil fuel, and alcohol industries together account for some 19 million deaths worldwide every year. In the WHO European region alone, more than 26,000 people die each year as a result of diets high in sugar-sweetened beverages. In The Lancet Diabetes & Endocrinology, authors discuss a new report from the WHO Regional Office for Europe on the commercial determinants of non-communicable diseases, which stresses the need for systemic reform: https://hubs.li/Q02GKqG30

📢 New findings on the impact of alcohol health-warning labels! The recent WHO/Europe study was conducted across 14 European countries with over 19,000 participants. Here are the key takeaways: 📈 Increased awareness: Exposure to cancer warning labels on alcohol significantly increased knowledge about the link between alcohol and cancer across all countries, regardless of the label format. 🏷️Acceptance of different labels: Cancer messages were perceived more impactful and relevant when compared to general health harm and responsibility messages. Among cancer messages, labels containing only text or including a warning symbol were perceived as more acceptable compared to labels containing graphic image. 👥 Universal Impact: The effect on knowledge was consistent across various demographic groups, making these labels a universal tool for educating the public about the risks of alcohol, including cancer. This study reinforces the importance of clear health warnings on alcohol containers. Consumers have the right to know about the risks associated with alcohol consumption, to make healthier and informed choices! For more details, read the full article here: https://bit.ly/4cXsUKb #AlcoholLabelling #AlcoholRightToKnow #EVIDACTION

Yesterday, our Series authors discussed the diverse challenges Asian nations face regarding the rising number of lung cancer incidences in the region. In case you missed it, you can now watch this webinar on-demand: https://hubs.li/Q02FRxss0 Our authors explored insights into drug development, the impact of climate change on lung cancer incidence, and the unique characteristics shaping the healthcare landscape for Asian populations.

🚨 Submission alert - we’re now inviting entries to our annual essay competition, the Wakley Prize. Put pen to paper and share your ideas on centring care in medicine. More here: https://hubs.li/Q02Fvm4K0

Projections suggest more than 30 million people may be diagnosed with cancer in 2040, a 67% increase in 20 years. The global burden of cancer is immense, growing, and afflicts low- and middle-income countries most severely. “The public health response should be commensurately ambitious”, say co-chairs of an upcoming Lancet Commission: the CONCORD–Lancet Global Commission on Cancer. Learn more about the Commission’s purpose and aims ⤵️ https://hubs.li/Q02Fvl9G0

Last week, The Lancet Planetary Health's editorial team hosted a webinar exploring the journal's aims and scope. They also shared what they are looking for in a research paper and best practices to prepare your manuscript for publication in their journal. Couldn't join us live? Catch up now on-demand! Watch now: https://hubs.li/Q02zcXdT0

Nearly one third of adults worldwide did not meet the recommended levels of physical activity in 2022, suggests a new study in The Lancet Global Health. Explore the data 👉 https://hubs.li/Q02DPxN_0 Figures: Map of (A) age-standardised prevalence of insufficient physical activity among adults aged 18 years and over in 2022, (B) data coverage and representativeness, and (C) country progress during 2010–22 toward the global target of a 15% relative reduction in insufficient physical activity prevalence among adults aged 18 years and over between 2010 and 2030

Low back pain covers a spectrum of different types of pain that frequently overlap, e.g.: - Nociceptive - Neuropathic and nociplastic - Non-specific In The Lancet, a Seminar provides a brief overview of the epidemiology, causes, and risk factors that contribute to low back pain. Authors also describe different therapeutic options. To a large extent, therapy depends on pain classification. Read here: hubs.li/Q02CYWKK0 👇 Figure: Sagittal view of lumbar spine showing potential pain generators