15 Actor Duos Who Have So Much On-Screen Chemistry, They've Played Couples In Multiple Movies

“I always knew he was very special. And he was very magnetic as an actor. We’ve always just felt very comfortable with one another,” Saoirse said about Timothée during a 2020 interview. “We’re very different in the way we work and the kind of performances that we give, and that really excites me – how different we both are.”

During a 2018 interview with Entertainment Tonight, Emma said that Ryan is a "dear wonderful friend" and she "can’t even imagine what [her] life would be without Ryan."

In a 2022 interview with GQ, Christian explained how he ended up serving as a "mediator" between Amy and American Hustle director David O. Russell. "I did what I felt was appropriate, in very Irv style," he said.

Javier and Penélope got together in real life after reuniting on the set of Vicki Cristina Barcelona, and they got married in 2010. Penélope has said that she and Javier don't typically try to work together but it does happen sometimes.  "It's not something we plan on doing every two years," she said. "That will be once in a while, if we feel it's right. I don't think it will be too often."

During a 2023 panel, Drew said her relationship with Adam is "all based in like, love, admiration and humor." She added that she only did the film Blended because he was doing it with her. "I feel so safe with Adam," she said. 

Jennifer once told Jimmy Kimmel that she considers Adam a part of her family after meeting at a deli in the '90s. "We were friends before Friends," she said. 

Omar has spoken about how he loves that Love & Basketball has had such a lasting impact. He said, "Monica and Quincy had a real friendship, and that’s the basis of every great relationship, which is really hard to do."

"I think we’re both just kind of weirdos," Kristen once said during an interview on the Today Show. "As a team, we’re a little bit less weird, because we get it from each other."

During a 2018 interview, Meg Ryan said she enjoys working with Tom because "he's just so easy." "He listens. He roots for other people," she added. "[Tom] doesn't like there to be drama."

During a 2015 interview with Deadline, Bradley said, "We don’t talk often, but when I showed up in Boston for Joy, then all of a sudden, it was like we never stopped. We just started where we left off, and that’s rare. It’s just easy to look at her and feel like I’m telling the truth."

Matthew has previously explained that rom-coms can only work unless the actors have a certain level of chemistry. "We had a really good push and pull," Matthew said in a video posted on his Twitter. “She had a lot of rock 'n' roll and I did too, the way we would parry with each other really worked in [How To Lose A Guy in 10 Days].”

All these years later, the two are still extremely close friends. "He was just very free with himself, and he had this effervescent energy that was really magnetic," she said about working on Titanic with him. "And I remember thinking, Oh, this is gonna be fun. We're definitely gonna get along. And we just really did. We just really did."

Keanu shared that they filmed the marriage scene in Bram Stoker's Dracula with a real Romanian priest, so technically they might actually be married IRL. "We did a whole take of a marriage ceremony with real priests," he said. "Winona says we are. [Francis Ford] Coppola says we are. So I guess we're married under the eyes of God." He joked that sometimes he'll even get texts from Winona that say "Hello, husband." 

The two have known each other since the early '70s and worked together several times. "He’s the sweetest man in the world. I don’t want to set the poor man up – he’s human, of course. But he’s one of the good guys," she said about Eugene during an interview with The Guardian. 

During an interview earlier this year, Mark said that working with Jennifer was ultimately what made him want to do 13 Going on 30. "It was Jen Garner, who is just magical, and we had just a wonderful chemistry together," he said.