Last updated on Aug 21, 2024

You're facing conflicting results from genetic testing platforms. How can you reconcile the discrepancies?

Navigating the maze of genetic testing can sometimes lead you to a crossroads of conflicting results. Imagine receiving different reports about your genetic predispositions or ancestry from various platforms. It's confusing and potentially distressing. But before you jump to conclusions, it's important to understand the intricacies of biotechnology and the reasons behind these discrepancies. Genetic testing is a complex process, and variability can arise from several factors, including differences in testing methods, data interpretation, and even the genetic markers each platform focuses on. Reconciling these conflicting results requires a careful and informed approach.

1 Verify Data

When faced with differing genetic test outcomes, your first step is to verify the raw data. This means going back to the source—the actual genetic information obtained from your DNA sample. Errors can occur during sample collection or sequencing, leading to discrepancies. Ensure that the sample was adequate and the sequencing quality meets the industry standards. If you have access to the raw data files, you can compare them across platforms to check for consistency. If inconsistencies are found at this stage, it may be necessary to consult with a genetic counselor or consider retesting.

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mouhssine leoub

Data Scientist | AI for Resource Exploration, Healthcare, agriculture
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one of the platforms is screwing up . I will redo a different test of a smaller and known sample on both of the platforms and see which one need to be tuned up

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2 Understand Methods

Understanding the testing methods used by different platforms is crucial. Each company may use different genetic markers or single nucleotide polymorphisms (SNPs) to analyze your DNA. These variations can lead to different interpretations of your genetic information. Some platforms may use broader, more generalized panels of SNPs, while others might focus on more specific sets that can affect the results. Familiarize yourself with the type of genetic testing technology each platform employs, such as whole-genome sequencing or targeted SNP genotyping, as this knowledge can shed light on possible reasons for conflicting results.

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3 Interpretation Variances

Differences in data interpretation are a common source of conflicting results. Genetic testing companies often use proprietary algorithms to interpret genetic markers, which can lead to variations in the risk assessments for certain diseases or conditions. Additionally, the scientific understanding of genetics is continually evolving, and platforms may update their interpretation models at different times. It's helpful to consider the context in which these companies operate and the fact that interpretations can change as new research becomes available.

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Alain Abi Rizk

Eng., PhD, Polymath, Associate Professor, Entrepreneur
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Differences in data interpretation are a common source of conflicting results in genetic testing. This is largely due to the use of proprietary algorithms by different companies to interpret genetic markers, which can result in varying risk assessments for certain diseases or conditions. Additionally, the scientific understanding of genetics is continually evolving, and companies may update their interpretation models at different times. These variations highlight the importance of being informed about the context in which genetic testing companies operate. As consumers or professionals, it’s crucial to recognize that interpretations are not static—they can change as new research becomes available.

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4 Consult Experts

If you're struggling to make sense of varying genetic test results, consulting with a healthcare professional or a genetic counselor is advisable. These experts can provide clarity by reviewing your results within the context of your personal and family health history. They have the expertise to interpret genetic data accurately and can explain the implications of your test results in a way that is relevant to you. Genetic counselors are also adept at helping you navigate the emotional aspects of learning about your genetic information.

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Saurav Jaiswal

Transforming Healthcare Through 🧬Genomics | Co-Founder @ Diverse Genomics | Entrepreneur | 🔬Biotech Visionary I Marketing & Sales Strategist📈
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When facing conflicting results from genetic testing platforms, I approach the issue by first cross-referencing the data with multiple sources to identify any inconsistencies. At Diverse Genomics, we rely on rigorous quality control measures and reanalyze the samples using different methodologies to ensure accuracy. I also consult with our team of experts to interpret the findings in context. By thoroughly investigating the discrepancies and considering all variables, we can reconcile the differences and provide the most reliable and accurate results to our clients.

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5 Reevaluation Over Time

Genetic science is not static; it's an ever-evolving field. What this means for you is that reevaluation over time is essential. As new discoveries are made and databases expand, previous genetic interpretations may change. It's wise to periodically review your genetic information with updated tools and knowledge. This approach not only applies to reconciling past discrepancies but also prepares you for understanding future developments in your genetic profile.

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Saurav Jaiswal

Transforming Healthcare Through 🧬Genomics | Co-Founder @ Diverse Genomics | Entrepreneur | 🔬Biotech Visionary I Marketing & Sales Strategist📈
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Genetic science is constantly evolving, and reevaluation over time is crucial. At Diverse Genomics, we’ve seen how new discoveries and expanding databases can change previous interpretations. For instance, an initial genetic risk assessment might shift as new research uncovers additional markers or updates existing ones. We advise clients to periodically review their genetic information with the latest tools and knowledge. This not only helps reconcile past discrepancies but also keeps them informed about future developments in their genetic profile. Staying updated ensures a more accurate and comprehensive understanding of their genetic health.

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6 Diverse Genetic Pools

Lastly, consider the diversity of genetic pools used by different platforms for comparison. Some companies may have more comprehensive databases that include a wider array of ethnic backgrounds, which can affect ancestry results and health risk assessments. If your genetic background is underrepresented in a company's reference population, this could lead to less accurate results. Understanding which populations are well-represented in a platform's database can provide insight into the reliability of your results and help reconcile differences.

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You're facing conflicting results from genetic testing platforms. How can you reconcile the discrepancies?

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1 Verify Data

2 Understand Methods

3 Interpretation Variances

4 Consult Experts

5 Reevaluation Over Time

6 Diverse Genetic Pools

Biotechnology

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