AmberGen reposted this
AmberGen is proud of its tradition of scientific innovation and a big part of that is the work done by our innovative scientists such as Leonardo Garcia Dettori, PhD. Leo did a great job on this foundational project where he demonstrated that the "soft ionization" associated with MALDI Mass Spectrometry does not destroy or consume a sample, leaving it available for subsequent imaging steps as part of a spatial multiomic workflow. Nice work Leo! #MALDI #IMSIS #ASMS
Biochemist | Molecular Biologist | Spatial Biologist | Structural Biologist | Bioinformatics Scientist | Bioprocess Engineer
I recently had the opportunity to represent AmberGen and present a poster at the American Society For Mass Spectrometry (ASMS) annual meeting this month. The poster reports a workflow we call 'Cyclic MALDI-IHC’. AmberGen’s Miralys™ MALDI-HiPlex-IHC is used to simultaneously image hundreds of intact proteins on a tissue section, tissue microarray, or single cells. The Cyclic MALDI-IHC workflow consists of reusing the same tissue section for successive imaging: (i) with the same panel of probes resulting in nearly identical images across cycles demonstrating this is a non-destructive workflow; (ii) with the same panel of probes at higher spatial resolution to image specific regions of interest; (iii) or image even with a completely different panel of probes to obtain additional biological information from precious samples. While this poster demonstrates successive cycles of MALDI-IHC, it also opens the doors for other multiomic and multimodal workflows (e.g., lipids, small molecules, drugs, transcripts) on the same tissue section. If you would like to learn more, contact us at AmberGen.com (info@ambergen.com). I am very grateful for the guidance of the scientific team at AmberGen including Prof. Kenneth Rothschild, Dr. Mark Lim, and Dr. Gargey Yagnik as well as our CEO, John Gillespie! #ASMS #MSI #spatialbiology #neuroscience #multiomic #multimodal #proteomics