American Society for Cell Biology (ASCB)

From MBoC USP34 regulates endothelial PAR1 mRNA transcript expression and cellular signaling, by JoAnn Trejo, UC San Diego Health, et al. This study reveals that the deubiquitinase USP34 regulates thrombin-stimulated PAR1-induced p38 signaling not by altering protein ubiquitination, but by increasing F2R mRNA expression, leading to higher PAR1 cell surface levels. These findings uncover an unexpected role for USP34 in modulating GPCR signaling through transcriptional control rather than direct posttranslational modification. https://lnkd.in/e2q6iynb #ASCB #CellBiology

From MBoC Traveling wave chemotaxis of neutrophil-like HL-60 cells, by Satoshi Sawai, University of Tokyo, et al. Using a microfluidic approach, this study examined how neutrophil-like HL-60 cells respond to traveling waves of chemoattractants, revealing that wave speed influences whether cells advance or retreat. Cell movement patterns correlated with Cdc42 activity, and pharmacological tests showed distinct roles for Cdc42 and ROCK in cell reorientation, suggesting that pulsatile waves can either recruit or disperse immune cells based on dynamic cues. https://lnkd.in/emKYeu8P #ASCB #CellBiology

Have a groundbreaking idea? Submit a proposal for #CellBio2025 and shape the scientific program. Whether it’s a focused discussion, workshop, or sponsored talk, bring your vision to life. Deadline: April 8 ➡️ https://lnkd.in/eN7ci388 #ASCB #CellBiology

Tomorrow’s the day! TN scientists, be ready to advocate for research funding at ASCB Tennessee Virtual Hill Day. Haven’t signed up yet? There’s still time! https://lnkd.in/e8PUwPir #FundScience #ASCB

From MBoC Beta-actin function in platelets and red blood cells can be performed by gamma-actin and is therefore independent of actin isoform protein sequence, by Anna Kashina, University of Pennsylvania School of Veterinary Medicine, et al. This study shows that replacing β-actin with γ-actin in mice does not affect red blood cell or platelet function, challenging the belief that β-actin’s protein sequence is uniquely suited for blood cell cytoskeletal roles. Instead, the enrichment of β-actin in these cells is likely driven by nucleotide-dependent functions rather than its amino acid sequence. https://lnkd.in/e7CDKCaX #ASCB #CellBiology

Why did you join ASCB? Whether it’s for networking, career growth, or resources, we’d love to hear your story! Share your experience and inspire others to join. 👇 https://lnkd.in/eFBMveZ #ASCB #CellBiology #ScienceCommunity #ShareYourStory

Join ASCB Tennessee Virtual Hill Day this Thursday, March 27, to speak with policymakers about federal research funding. Make an impact—register today! https://lnkd.in/e8PUwPir #ScienceMatters #ASCB

MBoC Traveling-wave chemotaxis of neutrophil-like HL-60 cells, by Satoshi Sawai, University of Tokyo, et al. A microfluidic study reveals that neutrophil-like cells respond differently to chemoattractant waves based on speed, moving forward in fast waves but reorienting or reversing in slower ones. FRET-based analysis links these movement patterns to Cdc42 activity, suggesting that pulsatile waves can recruit or disperse neutrophils depending on wave dynamics. https://lnkd.in/emKYeu8P #ASCB #CellBiology

TN scientists! Join ASCB Tennessee Virtual Hill Day on Thursday, March 27, to advocate for science funding. Speak directly with policymakers—your voice matters! Sign up now: https://lnkd.in/e8PUwPir #ASCB #ScienceAdvocacy

Call for Proposals is Open! #CellBio2025 offers diverse session formats—from deep dives to interactive workshops and sponsored talks. Start your proposal now and submit by April 8. Submit today ➡️ https://lnkd.in/eN7ci388 #ASCB #CellBiology