Aligning Science Across Parkinson’s | ASAP

We are excited to announce two new competitive #FundingOpportunities under the Collaborative Research Network (CRN) for research teams addressing high-priority questions in #ParkinsonsDisease. These #grants will support multidisciplinary, international, and multi-institutional teams working to accelerate the pace of discovery for #PD and drive new ideas into the R&D pipeline. Letters of Intent will open in early 2025. 🗓 Learn more about the CRN and how to apply: https://lnkd.in/gwDatAMX #CRNFundingOpportunity

You don't want to miss this 🚨 The November installment of the Mito911 #webinar series will feature Reuben Shaw, PhD from the #SalkInstitute of Biological Studies, on November 7 at 11:00 am ET. Use the link below to reserve your spot. https://bit.ly/3C97HQg

The mitochondrial unfolded protein response (UPR) is a mechanism utilized by mitochondria to maintain proteostasis and promote recovery during stress conditions. The impact of the mitochondrial stress response in the human brain is uncertain. Here, Team Schapira utilizes iPSC-derived models to assess the role of mitochondrial UPR in specific cell types 🧪 Check out the #preprint here: https://lnkd.in/g5dY_nEB

A hallmark of neurodegenerative diseases such as #ParkinsonsDisease is the progressive loss of proteostasis, leading to conversion of proteins from productive folding pathways to populate aggregation-prone misfolded (non-native or intermediate) states 🔬 To combat this toxicity, cells have evolved degradation pathways (ubiquitin-proteasome system and autophagy) that detect and degrade misfolded proteins. In this preprint, Team Harper found that aggregation burden dictates the activation of proteasome-dependent quality control pathways. Read the #preprint here: https://lnkd.in/dwSyXxeN

In their recent publication, Team Calakos introduces a new open-source tool for counting synapses called SynBot 🔬 SynBot allows researchers to quickly and easily measure changes in synapses using regular fluorescence microscope images. SynBot does this through automated image analysis techniques, including machine learning tools to tell the difference between real synapses and noise. They use this tool to determine how synapses are altered in PD models. Read the #publication here: https://lnkd.in/gemKaZgA

We're celebrating James Surmeier & Vernon Clarke from Team Surmeier as our October #OpenScience Champions🏆 They worked diligently to ensure the links on a recent publication were functional! Thank you, James and Vernon, for your work! Read Team Surmeier's recent #publication: https://lnkd.in/gVcEXr_b

Team Studer developed a suite of #ParkinsonsDisease iPSC models that can be utilized to study how genetic manipulations impact PD-related inclusion pathologies 🧬 Learn more about their work here: https://bit.ly/3YB88vo

Enhanced activation of kinase activity in LRRK2 is associated with #ParkinsonsDisease. In their preprint, Team Reck-Peterson presents the development of LRRK2-selective type-II kinase inhibitors, which were designed using a combinatorial chemistry approach 🧪 Read their #preprint to learn more about how these inhibitors: https://lnkd.in/gbTjqEFs

We are celebrating members of the Single Cell Mulit(omics) working group as our October Network Spotlight 💡They generated a guide on how to write README files for code. Check out the guide on Zenodo: https://lnkd.in/g_C44XyY

Sharing data in publicly accessible repositories is a key component of the FAIR Guiding Principles for Scientific Data Management and Stewardship, however, data associated with publications are often not made publicly available. Our new #blog series, The Stories that Drive ASAP's Open Science Policies, by Dana Cobb Lewis, PhD, highlights the critical role of data sharing to accelerate the pace of scientific discovery by allowing others to build upon the work of those who came before 🔬 Click the link to learn more: https://lnkd.in/etByeR6G