Berry Consultants, LLC

This month’s FACTS Software webinar will be on August 23rd at 11am EDT and will focus on interactive results exploration and visualization in FACTS.  FACTS developer Elias Meyer will present on how to learn more about your designs and create bespoke figures using the R Shiny App AIRSHIP. To join this session (free and open to the public), please register in advance on our website at: https://lnkd.in/eZzF_tEb

Berry Consultants is proud to sponsor next week’s ASA #JSM2024!  Stop by our exhibit booth #101 to meet the team, learn more about our adaptive clinical trial design and implementation services, and get a demo of our latest software products.  Hope to see you there!

I'm presenting a free webinar this Friday on the idea of "continuous enrollment" in dose escalation oncology trials rather than "cohort enrollment". The idea has been around in various forms for nearly the last ten years - the Roling 6 design, Anastasia Ivanova's "Rapid Enrollment", the option to "Backfill" in BOIN. Whilst we are waiting for the current cohort to complete, if another patient becomes eligible for our trial rather than turning them away ("losing" them) can we enroll them in our trial in a useful but not risky manner? Our trial might enroll more subjects, but it might also complete more quickly which might be an attractive trade-off. In our FACTS trial simulation software, for some years we have had the option to include this in the simulation of CRM (a.k.a Baysian Logistic Regression) designs but the options and simulated behavior are quite complex, so in this talk we lift the veil and look and it all works. If your interested in attending the webinar or would like to receive a link to the recording once its complete, please register here: https://lnkd.in/eysDYJS4 Best Regards, Tom Parke, Berry Consultants

Dr Philip White and Dr Melanie Quintana of Berry Consultants, LLC presented data from our successful Phase 1 MEND study at the annual meeting of #ENCALS. The data highlighted the statistically significant survival benefit for patients treated with monepantel compared to untreated matched-controls from the PRO-ACT database: https://buff.ly/4c4eyHF #MND #ALS Click here to view the poster being presented: https://buff.ly/4esMdMJ Click here to view a video of Dr Philip White presenting the poster: https://buff.ly/3VLOQ51

Reminder don’t miss this Friday’s June 21st summer seminar of the Viennese Section of the International Biometric Society that is co-organized by the Medical University of Vienna and Berry Consultants. For more information, please see our website link at:  https://lnkd.in/gfZi2wKw

Berry Consultants is excited to sponsor and present at next week’s PSI: Statisticians in the Pharmaceutical Industry Conference in Amsterdam on June 16th - 19th. Stop by booth #12 to meet our team and learn more about our consulting and software solutions!  In addition, the following Berry Consultants team members will be presenting: •Mon. June 17, 17:00-19:00 Poster session, Amy Crawford will be presenting a poster on “Precision Medicine in Practice: Adaptive enrichment design to find treatment-sensitive patients in a stroke platform trial”. •Tues. June 18, 10:45-12:15 session on Bridging The Gap Between Bayesian & Frequentist Adaptive Designs, Cora Allen-Savietta will present “Forecasting with Confidence: Harnessing Predictive Probabilities in Practice”. •Tues. June 18, 10:45-12:15 session on Recent Developments of Advanced Randomization Designs, Peter Jacko will present “A fair and efficient randomization scheme for multi-arm seamless two-phase clinical trials”. •Tues. June 18, 14:15-15:45 session on Innovative Dose Escalation Designs, Tom Parke will present “Comparing Dose Escalation Methods: i3+3, mTPI, BOIN, Bayesian Logistic Regression (CRM)”. •Wed. June 19, 13:30-14:30 session on Master Protocols, Elias Laurin Meyer will present “Designing an exploratory phase 2b platform trial in NASH with correlated co-primary binary endpoints”. Hope you can catch a few of our sessions! For more information about #PSIConference2024 and the entire program, please see: https://lnkd.in/gPQzjb7N

For next month’s FACTS Software June Webinar, the software team will be presenting an early look at the new features of the upcoming FACTS 7.1 release. A few of the new features that will be demonstrated include: •In the Platform Trial simulator, concurrent control analyses of posterior probabilities, predictive probabilities, and p-values are now available. •In the Dose Escalation simulator with open enrollment, the facilities for controlling how many “at risk” subjects are allowed has been improved, and options for “backfilling” extended. •For binomial endpoints, the Fisher’s Exact Test and Bayesian Beta Binomial analyses are included. •“AIRSHIP”, a new R graphing package, has been integrated with FACTS to facilitate lattice plots comparing operating characteristics across multiple dimensions. •“Tooltip” help has been developed to provide quick explanations to various input fields for users. This will continue to be developed and rolled out across all input fields of FACTS in future releases. To join the June 14th, 11am EDT session (open to the public), please register for the Zoom webinar in advance: https://lnkd.in/ebxDUmMr

Berry Consultants team members are excited to be attending and presenting in multiple sessions at next week’s 45th Annual Meeting of the Society for Clinical Trials (SCT) in Boston, MA.   -On Tues, May 21st at 4pm EST, Jessica Overbey is the session organizer and a panelist for the Invited Session #16, “Opportunities for Patient Centered Trial Design in Rare Disorders”. -Also at 4pm EST on Tues, May 21st, Cora Allen-Savietta, Liz Lorenzi, Giorgio Paulon, and Will Muerer will present in the Invited Session #17, “Forecasting with Confidence: Harnessing Predictive Probabilities in Practice”. -On Wed, May 22 at 10:45am EST, Melanie Quintana will be presenting in Invited Session #26, “The HEALEY ALS Platform Trial: Efficient Design and Implementation of new Regimens”. For more information about these sessions, the conference program, and registration, please see: https://lnkd.in/gFkwbwMs   Hope to see you there! #SCT2024

Peter Jacko of Berry Consultants will be presenting in this week’s annual ADMTP (Adaptive Design and Multiple Testing Procedures) Workshop. His presentation will focus on designing a platform trial for Neurofibromatosis type 2 and the key of running simulations (using the R package “SIMPLE” – SIMulating PLatform trials Efficiently) as part of the design process. For more about the April 25th-26th ADMTP workshop and sessions, please see link here: https://lnkd.in/gaD2wt_S

For next week’s FACTS Software April Webinar, the Berry Consultants Software team will present an early look at an optimization project the team has started that explores an automated process to search for an "optimal" design when the design must be simulated to evaluate its operating characteristics. In addition, the team will look at a process for extracting early stopping boundaries from simulations for adaptive designs where no closed form method exists. Plan on joining us!   For advance Zoom registration for this April 26, 11am EDT session (open to the public), please register here: https://lnkd.in/g7-Qbs2G