As we approach the ASCO 2024 annual meeting, and look forward to presenting our newest poster, we would like to take this opportunity to revisit some of our past scientific posters & abstracts.
Study Published in Neuro-Oncology Advances Highlights Innovative Approach to Personalized CNS Drug Delivery for Leptomeningeal Disease
2023 – A groundbreaking study, titled "Dynamic Control of CSF for Personalized CNS Drug Delivery for Leptomeningeal Disease," has been published in Neuro-Oncology Advances, Volume 5, Issue Supplement_3, in August 2023.
Led by Priya Kumthekar, MD, and Hector Ribeiro Benatti, PhD, the research team includes Toloo Taghian, Seema Nagpal, William Gormley, William Baker, Rajan Patel, Emma Brown, Marcie Glicksman, and Heather Gray-Edwards. Their study introduces an innovative approach to drug delivery in central nervous system (CNS) diseases, particularly leptomeningeal disease, aiming to improve therapeutic outcomes.
Effective treatment of brain metastases and leptomeningeal disease requires appropriate drug distribution within the CNS. However, inadequate drug bioavailability often contributes to poor patient outcomes. EnClear Therapies has developed a device that delivers intrathecal therapeutics using dynamic control of cerebrospinal fluid (CSF) flow through an external pump. This novel system has the potential to enhance drug delivery and improve treatment efficacy.
The study investigates the intrathecal delivery of methotrexate using EnClear's system and assesses its impact on drug concentration in CNS tissue in sheep and non-human primates. Preliminary findings suggest promising results, highlighting the potential of this innovative approach to revolutionize CNS drug delivery.
The publication in Neuro-Oncology Advances underscores the importance of advancing novel technologies to address unmet clinical needs in neuro-oncology and beyond.
For media inquiries and further information about the study, please contact EnClear Therapies at https://lnkd.in/eX7MvQ_i.
About Neuro-Oncology Advances:
Neuro-Oncology Advances is a leading peer-reviewed journal dedicated to publishing high-quality research and advancements in the field of neuro-oncology. It serves as a platform for disseminating innovative findings that contribute to improving patient care and outcomes.
The study "Dynamic Control of CSF for Personalized CNS Drug Delivery for Leptomeningeal Disease" is available online at DOI: https://lnkd.in/ew2v3uAH.
Marcie GlicksmanRajan PatelKevin KalishAnthony DePasqua
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