Cancer Reports

Suleiman et al. presented two cases of locoregional recurrence of PIK3CA-mutated head & neck squamous cell carcinoma (SCC). After failure of chemotherapy, combinatorial immunotherapy led to better response.   Full text: https://lnkd.in/d4MMZi46   #CancerReports #Wiley #OpenAccess #CaseReports #CaseSeries #Recurrence #Metastasis #HeadAndNeckSquamousCellCarcinoma #HNSCC #Alpelisib #Immunotherapy

Kolck et al. showed that body composition analysis of preoperative computed tomography images of patients with intrahepatic cholangiocarcinoma is a better tool for risk stratification than body mass index. Full text: https://lnkd.in/dzYzyYbj #CancerReports #Wiley #OpenAccess #IntrahepaticCholangiocarcinoma #ComputedTomography #BodyComposition #Perioperative #Retrospective

#BreastCancerAwarenessMonth ! Check out the Cancer Reports website for the latest research & review articles on Breast Cancer! https://lnkd.in/dukiKHaK We publish basic, translational, clinical & interdisciplinary research in cancer biology, diagnosis, treatment, outcome, supportive care, epidemiology & health disparities.   #CancerReports #Wiley #OpenAccess #BreastCancer #October #Awareness #Oncology

Wang et al. demonstrated DOT1L as a target of dexamethasone in B-lymphoma. Silencing expression of DOT1L reduced growth of B-lymphoma cells. Specifically, they showed that dexamethasone decreased DOT1L expression in dexamethasone-sensitive B-lymphoma cells & MLL-rearranged leukemia cells, but not in dexamethasone-insensitive acute monocytic leukemia cells. This suggested that DOT1L may be an underlying novel indicator of dexamethasone sensitivity against hematological malignancies. Full text: https://lnkd.in/dhTaUcbm #CancerReports #Wiley #OpenAccess #Dexamethasone #Lymphoma #DOT1L

Yang et al. analyzed performance of a blood test for detecting hepatocellular carcinoma— dual-target HCC blood test (DT-HBT)—using GNB4 & Riplet methylation. Study suggested DT-HBT to be a reliable & high-performing blood test for diagnosis & monitoring of HCC. Full text: https://lnkd.in/df7kgS8Z #CancerReports #Wiley #OpenAccess #BloodTest #DTHBT #HepatocellularCarcinoma

Adaranijo et al. applied grounded theory research method to examine the self-identities of women with breast cancer in Nigeria. The study suggests emergence of three self-identities: (1) valued self-identity before breast cancer; (2) dependent and determined self-identities during treatment; & (3) devalued self-identity post-treatment. Study may allow caregivers to understand profound perpetual psycho-emotional impact that breast cancer has on sufferers & survivors. Full text: https://lnkd.in/gXXpZYBA #CancerReports #Wiley #OpenAccess #BreastCancer #SelfIdentity #Nigeria

Prior studies have shown that myeloproliferative neoplasm (MPN) with JAK2-V617F mutation has an increased expression of programmed death-ligand 1 (PD-L1) in megakaryocytes leading to cancer immune evasion by inhibiting T-lymphocytes. Recently, Ibrahim et al. compared PD-L1 expression in bone marrow (BM) of patients with JAK2-mutant & JAK2-negative MPN, with normal controls. Results suggest that patients with JAK2 mutation have a higher PD-L1 expression in megakaryocytes than that in normal controls. A combination of checkpoint and JAK2 inhibitors may be an active treatment option. Full text: https://lnkd.in/dQbFHQjg #CancerReports #Wiley #OpenAccess #MyeloproliferativeNeoplasm #JanusKinase2 #PD_L1

Morita et al. conducted retrospective observational study on patients with EGFR-positive NSCLC with postoperative recurrence. Metastasis to the CNS & bone were poor prognostic factors. Study may potentially help clinicians to determine the timing of administering osimertinib to the patients. Full text: https://lnkd.in/dzsDCkpv #CancerReports #Wiley #OpenAccess #NonSmallCellLungCancer #NSCLC #EGFR #PostoperativeRecurrence #Prognosis #Metastasis

A review by Guo et al. discusses therapeutic potential of terpenoids in targeting mitochondria to induce cancer cell death. Terpenoids lead to apoptosis, pyroptosis, necroptosis, ferroptosis, autophagy, & necrosis caused by mitochondrial permeability transition. Full text: https://lnkd.in/dkpFY7rw #CancerReports #Wiley #OpenAccess #Review #Terpenoids #Mitochondria #Cancer #CellDeath

Wilson et al. present a case with metastatic non-myofibroblastic sarcoma with EML4-ALK fusion. First description tracking development of resistance mutations. The case study questions utility of presence of G1202R mutation as marker of #lorlatinib sensitivity in non-lung ALK rearranged tumors, contrary to experience in lung cancer. Full text: https://lnkd.in/dUr3F6xY #CancerReports #Wiley #OpenAccess #CaseStudy #CaseReport #NonMyofibroblasticSarcoma #EML4_ALK #Chemotherapy #Alectinib