Cell Research

🔬 September Issue Release! In this month's cover story, the Chinese legend "The Magic Brush" illustrates the challenges in protein engineering, symbolized by a towering mountain representing the rugged protein fitness landscape. 🏔️ Peng Cheng et al. introduce ProMEP, a groundbreaking AI-powered tool that acts like a “magic brush,” swiftly guiding scientists to the summit of protein engineering success. The AI technology behind ProMEP helps biologists explore new solutions faster than ever before. Explore the full article on pages 630-647. Read more: https://lnkd.in/ePtqWWXH #AI #ProteinEngineering #Biotech #ScientificResearch #Innovation

🌱 Unlocking the Secret to Longevity through Calorie Restriction 🧬 In a recent study published in Cell Research, Li et al. have uncovered how the AMPK-PDZD8-GLS1 axis mediates the anti-aging effects of calorie restriction (CR). By enhancing glutaminolysis, this pathway triggers a mild increase in mitochondrial reactive oxygen species (ROS), improving mitochondrial function and ultimately extending lifespan—a process known as mitohormesis. Discover how these findings could reshape our understanding of aging and longevity by exploring the full article here: https://lnkd.in/ejnQ96xA #LongevityScience #MolecularBiology #CellResearch #AntiAging #Mitochondria

🧠 PCDH10 Identified as a Key Neuronal Receptor for Western Equine Encephalitis Virus (WEEV) 🦠 In a new study published in Cell Research, Dr. Yan-Yi Wang’s group from Wuhan Institute of Virology uncovers that PCDH10 plays a critical role as a neuronal receptor for WEEV, a highly pathogenic encephalitis virus. This discovery offers promising potential for antiviral strategies, with the study suggesting that soluble PCDH10 and its blocking antibodies could act as effective therapies against WEEV infection. Explore how this breakthrough could pave the way for novel antiviral treatments: https://lnkd.in/eEePHCSx #Virology #AntiviralResearch #CellResearch #Encephalitis

The October issue of Cell Research is now available! This issue offers 6 cutting-edge research highlights, 3 full-length articles, and 3 letters to the editor. This issue discusses advancements in cellular metabolism, cancer immunotherapy, and SARS-CoV-2 evolution. Highlights include breakthroughs in metabolic adaptation, T cell suppression in tumors, and viral mutations driving human adaptation—advancing our fight against disease. Stay updated with the latest breakthroughs and access the full issue here 👇 https://lnkd.in/eBDTmVHm #CellResearch #MolecularBiology #ScientificInnovation #CellSignaling #AI

Check out October’s cover story, inspired by the tale of General Lian Po from the Warring States period, who was re-energized by a chunk of meat. 🍖 Discover how amino acid glutamine catabolism re-energizes cells when glucose is depleted, as detailed by Mengqi Li et al. on pages 683–706. https://lnkd.in/etj9HUxw #MolecularBiology #CellMetabolism #Glutamine #Cancer

🌾 New Research Uncovers Key Mechanism in Hybrid Rice Fertility 🌡️ A recent study has identified the crucial role of TMS5 as a tRNA 2’,3′-cyclic phosphatase, vital for the recycling of mature tRNAs. This process is essential for maintaining male fertility in hybrid rice, particularly under high-temperature conditions, which are becoming more common due to climate change. The findings highlight how mutations in TMS5 disrupt this function, but innovative gene-editing strategies are showing promise for restoring fertility. These insights are significant for the development of more resilient rice varieties, a key factor in ensuring global food security. Explore the full study to learn more about how these breakthroughs could transform the future of rice breeding and crop sustainability: https://lnkd.in/dpiWk36c #HybridRice #PlantGenetics #FoodSecurity #RiceBreeding #AgriInnovation #CropScience

The September issue of Cell Research is now live! 🌟 Explore the latest scientific advances with 6 cutting-edge research highlights, 1 in-depth review article, 2 articles, 2 thought-provoking letters to the editor and 1 correction. This issue includes breakthrough discoveries in protein engineering and AI-powered methodologies that are set to redefine research practices. Stay informed and access the full issue here 👇 https://lnkd.in/ePtqWWXH #CellResearch #ScientificInnovation #ProteinEngineering #AI

The September issue of Cell Research is now live! 🌟 Explore the latest scientific advances with 6 cutting-edge research highlights, 1 in-depth review article, 2 articles, 2 thought-provoking letters to the editor and 1 correction. ⛰️ This issue includes breakthrough discoveries in protein engineering and AI-powered methodologies that are set to redefine research practices. Stay informed and access the full issue here 👇 https://lnkd.in/ePtqWWXH #CellResearch #ScientificInnovation #ProteinEngineering #AI

🔬 Breakthrough in Protein Design! Scientists have successfully designed heterochiral protein interactions from scratch. 🧬 This opens doors to using mirror-image proteins as potential new therapies, revolutionizing biomedicine. Curious how this could shape healthcare? Discover more here: https://lnkd.in/eikaazRD #Biomedicine #ProteinDesign #Therapeutics #Healthcare #Innovation

📊 Unlocking Chromatin Structure! Li et al.'s groundbreaking study presents the 3.6 Å resolution cryo-EM structure of H5-bound chromatin fiber. This detailed atomic model of the chromatosome reveals key insights into how nucleosomal arrays fold into higher-order chromatin, both in vitro and in vivo. Dive into the full research here: https://lnkd.in/eEyq75RS #ChromatinStructure #MolecularBiology #CryoEM #Chromatosome