Chemspace

Exciting News 🚀 We have updated Enamine REAL Space on our website, now offering easy access to over 75 billion molecules! https://buff.ly/44GRYAs Navigate Enamine REAL and Freedom Spaces effortlessly to explore hits, discover new analogs, and perform scaffold hopping. Powered by FTrees technology from BiosolveIT, our platform brings efficient searching to your fingertips. Why REAL and Freedom Spaces? These are make-on-demand compounds with a 75%+ synthesis success rate and a 4-5 week lead time, thanks to carefully selected reaction protocols and in-stock building blocks. 💡 From now on, you can get molecules from Freedom Space 3.0 at an accelerated pace. Our collaboration with Enamine`s Germany Site has reduced delivery times, allowing you to start your research even faster. #chemspace #openscience #research #science #drugdiscovery #chemicals #medicinalchemistry #drugdevelopment #chemistry #researchanddevelopment #chemicalindustry #science

If you’re looking for a solution that meets the demands of high-sensitivity research while streamlining your lab’s workflow, Micro Fast ELISA kits by Reed Biotech LTD are the answer. Specifically designed for small sample volume detection, like cytokines, these kits are a game-changer for anyone in high-precision research. Why Choose Micro Fast ELISA Kits? ✅Less Sample Needed. Only 25μL of sample is required, making it ideal for studies with limited material. ✅Time-saving. Operation time is shortened by 30-60 minutes compared to traditional ELISA kits - faster results without compromising quality. ✅Enhanced Sensitivity. Sensitivity levels from 0.47 pg/mL to 47 pg/mL ensure high-accuracy results. Get high-quality, reliable data faster and with less sample waste. Don’t miss an exclusive 25% discount on specific Micro Fast ELISA kits, bringing unmatched efficiency to your research. Contact us at sales@chem-space.com to order or learn more about this limited-time offer! #chemspace #openscience #research #science #drugdiscovery #chemicals #medicinalchemistry #drugdevelopment #chemistry #researchanddevelopment #chemicalindustry #science 

Exciting news! Our General Pre-Plated Library now features over 917K screening compounds! Follow the link and download the library now: https://buff.ly/3YDlRBS Streamline your HTS workflow with our General Pre-Plated Library—ready-to-use, high-quality compounds from trusted suppliers Enamine and UORSY. Here is why it stands out: ✅Compounds pre-dissolved in DMSO for faster formatting and delivery ✅Reliable sourcing from world-renowned producers ✅Cherry-picking options for precise selection ✅Compounds at competitive prices We at Chemspace also offer over 60 pre-plated focused libraries for fast and effective hit identification. Each library is carefully curated, featuring compounds specifically chosen based on unique criteria tailored to its focus. Explore our libraries and streamline your discovery process! If you are interested or have any questions, contact us at sales(AT)chem-space.com. #chemspace #openscience #research #science #drugdiscovery #chemicals #medicinalchemistry #drugdevelopment #chemistry #researchanddevelopment #chemicalindustry #science

This year’s Nobel Prize winners underscore the rising significance of Artificial Intelligence. However, as Guy Durant highlights in Nature Computational Science, applying AI to drug discovery poses several challenges. The main issue is the complexity of drug discovery, which involves numerous variables that need careful integration. This complexity often leads to machine learning models underperforming without significant adjustments. Data management is another critical challenge. Advancing AI in drug discovery requires substantial effort in generating, curating, and storing large amounts of open data for future model training and evaluation. Blogpost: https://lnkd.in/d_Wy-Zwh Original paper: https://lnkd.in/ddiSvs-m #ML #AI #DrugDiscovery

Special offers on DEL-ML-CS workflow and HitGen OpenDEL 4.0 library! 🔥 Do not miss the chance to revolutionize your drug discovery research with cutting-edge technology and save on the most advanced screening solutions. #chemspace #DEL #ML #research #science #drugdiscovery #chemicals #medicinalchemistry #drugdevelopment #chemistry #researchanddevelopment #chemicalindustry #science

October is Breast Cancer Awareness Month worldwide. We join the global community in highlighting the importance of early detection, diagnosis, and control management of this dangerous disease. In October 2024, the FDA approved a new drug, inavolisib, in combination with palbociclib and fulvestrant, for the treatment of specific advanced breast cancer cases. Inavolisib contains a 1,3-oxazolidin-2-one fragment in its structure, which is found in other compounds that exhibit biological activity toward various targets, involved in the development of different pathologies. This is why we offer a set of in-stock and MADE building blocks that you can use to design promising drug candidates (https://buff.ly/4hcrzlB). Inavolisib (Itovebi, Genentech, Inc.) is a selective PI3K-alpha inhibitor used in combination therapy for adults with endocrine-resistant, PIK3CA-mutated, hormone receptor (HR)-positive, human epidermal growth factor receptor 2 (HER2)-negative, locally advanced or metastatic breast cancer. #chemspace #openscience #research #science #drugdiscovery #chemicals #medicinalchemistry #drugdevelopment #chemistry #researchanddevelopment #chemicalindustry #science

Chemspace and Enamine Ltd. are excited to announce a collaboration that will enable the delivery of molecules from Freedom Space in just 4-5 weeks! With Enamine's synthesis expertise and production capabilities, we are ensuring a fast and efficient process to get you the compounds you need. This collaboration reflects our commitment to providing global research teams with the best tools and resources, helping drive innovation at every stage. https://lnkd.in/e3qS4Hex #chemspace #openscience #research #science #drugdiscovery #chemicals #medicinalchemistry #drugdevelopment #chemistry #researchanddevelopment #chemicalindustry #science

Last week, the Nobel Prize in Medicine or Physiology was awarded to Victor Ambros and Gary Ruvkun “for the discovery of microRNA and its role in post-transcriptional gene regulation”. MicroRNAs (miRNAs) are small non-coding RNAs that play important roles in fundamental cellular processes, including cell proliferation, differentiation, apoptosis, and more. Dysregulation of miRNA expression is associated with a wide range of diseases, such as cancer, cardiovascular, neurodegenerative, inflammatory, autoimmune diseases, and metabolic disorders. Thus, the importance of Victor Ambros and Gary Ruvkun`s discovery lies not only in understanding of new mechanism of gene regulation but also in its significant implications for disease research, as well as the potential it opens for therapeutic applications by targeting miRNAs. At Chemspace, we provide a broad selection of products for miRNA functional and gene regulation studies in vitro and in vivo, enabling the investigation of their involvement in normal biological and disease pathways and the identification and validation of miRNA targets (https://buff.ly/3A7OygT). In addition, we provide custom miRNA and RNA synthesis services specifically designed to support your unique research goals. Contact us at sales@chem-space.com. Partner with Chemspace for cutting-edge solutions! Select from our premium miRNA products and take advantage of our bespoke synthesis services to create tailored miRNA and RNA molecules that meet the specific needs of your lab. #chemspace #openscience #research #science #drugdiscovery #chemicals #medicinalchemistry #drugdevelopment #chemistry #researchanddevelopment #chemicalindustry #science

Discover the faces behind the scenes as we keep introducing our talented team. Get ready to meet our QA Engineer – Daryna Horobei!     Daryna was happy to share a bit about her hobbies, and the first thing she mentioned was her love for drawing. She enjoys painting landscapes and still lifes the most. Swipe through the photos to see her incredible artwork! 🎨    She is also passionate about running - her favorite way to kickstart the day and stay fit. And when she is not running or painting, you will find her hiking in the mountains. Daryna told us all about her adventures with so much enthusiasm, saying how much she enjoys spending time outdoors with friends and family.    We are truly lucky to have such talented and inspiring people on our team!💚 Follow us to get to know more of our amazing colleagues! 

Fragment growing inside Enamine REAL developed by our team is getting more popular, so we decided to do a small case study to show how it works to help this approach reach a broader audience. Check out the article here: https://lnkd.in/e6w6GDnv In this work, we are going to grow and link fragments obtained from a fragment screen for the Nsp3 macrodomain of SARS-CoV-2 from https://lnkd.in/eB4bGycw. To simplify the fragment growing process and ensure that your fragment is expandable with REAL chemistry, we strongly recommend using the specifically designed fragment library: https://lnkd.in/eNjXXu-W