Clinical Trials Transformation Initiative (CTTI)

Thank you #PCORI for inviting me to speak on the Future of Patient- and Community-Engaged Comparative Effectiveness Research at the #PCORIAnnualMeeting2024. And thank you to the Clinical Trials Transformation Initiative (CTTI) members and experts from across the enterprise who made possible the CTTI work on #diversity and #patient group engagement that informed so many of the key considerations and resources I was able to draw from.   A few other highlights from the meeting: - Learning about the various interventions, e.g., patient navigators, telemedicine, used to support treatment of Hepatitis C in those who use drugs. Plus it’s incredible to see how effective SOF/VEL x 12 weeks can be even with mixed levels of adherence in real-world settings. - Appreciating the depth of the youth mental health crisis and the barriers to access in care, the pressure on clinicians, the improving but enduring stigmatization – and on the flip side, the potential for peer support, more routinized screening, and sharing vulnerabilities and personal stories to drive a wedge in. - Getting to meet in-person and learn from my brilliant conference bestie Dr. Chidinma Ibe about trustworthiness and the power of creating genuine, reciprocal relationships with community health workers.     Grateful to Greg Martin, Ashley Pidal, Anne Trontell, Nakela Cook and the full PCORI team for a terrific meeting.

Today at 1:15 p.m. EDT! Summer Starling, DrPH, MPH will take the stage at the Colorectal Cancer Canada Patient-Centered Approach to Clinical Trials conference to highlight the importance of CTTI’s Transforming Trials 2030 Vision and how it champions patient involvement in clinical research. Discover how Canada can adopt this visionary framework and integrate patient perspectives into every aspect of clinical trials through the '5 Pillars.' Together, we can create a more inclusive and effective approach to clinical research. https://bit.ly/CTTIevents  

Tomorrow at 11:30 a.m. EDT, join CTTI’s Sara Bristol Calvert at American Public Health Association (APHA)’s Annual Meeting to learn how organizations can enhance their clinical trials infrastructure to better serve historically underrepresented populations using CTTI’s Diversity recommendations and Maturity Model. #APHA2024 https://bit.ly/CTTIevents  

Heading to American Public Health Association (APHA)’s Annual Meeting & Expo next week? Mark your calendar for October 29th and join Sara Bristol Calvert to learn about CTTI’s Diversity recommendations and Maturity Model.  This presentation will delve into how organizations can enhance their clinical trials infrastructure to better serve historically underrepresented populations. It’s time to ensure that clinical research reflects the diversity of our communities and meets their needs.    #APHA2024 https://bit.ly/CTTIevents  

CTTI Executive Director Morgan Hanger recently had the opportunity to sit down with Vera Kovacevic from Xtalks for a podcast interview that was published today. In the interview, Morgan discusses her career journey from PatientsLikeMe and Memorial Sloan Kettering Cancer Center to leading CTTI, and how her patient-centered focus has shaped CTTI’s approach to the Transforming Trials 2030 vision. Morgan also addresses major challenges in clinical trials, such as regulatory complexities and the need for better data transparency, explaining how CTTI is tackling these issues through collaboration and innovative trial designs to improve efficiency and inclusivity. The podcast episode is available on multiple platforms, including Spotify and YouTube. You can listen to it on YouTube here: https://lnkd.in/g426fs4D.

We’re thrilled to announce that Summer Starling, DrPH, MPH will be presenting at the Colorectal Cancer Canada Patient-Centered Approach to Clinical Trials conference on October 29th! Her session will focus on CTTI's Transforming Trials 2030 Vision, exploring how this innovative framework can shape the future of clinical research. Dr. Starling will discuss how Canada can embrace this vision and ensure that patient thinking is embedded across the '5 Pillars' of trial design. Learn how we can enhance the clinical trial experience for patients everywhere. https://bit.ly/CTTIevents  

CTTI is excited for Summer Starling, DrPH, MPH to share our MTT Framework at Colorectal Cancer Canada's upcoming PACT conference!

Disease progression modeling integrates a variety of data sources to inform #clinicaltrial design and support regulatory decision-making. A new Clinical Trials Transformation Initiative (CTTI) publication reviews current applications of #DPM and opportunities to advance the usage of DPM in clinical trials. CTTI conducted a scoping literature review and convened with experts across the clinical trials enterprise to understand how DPM is currently being used in trials and identify key areas that need to be addressed to incorporate DPM approaches more effectively in medical product development and regulatory decision-making. Read more: https://bit.ly/3Yt9zfw

Protas and Duke Clinical Research Institute (DCRI) formed a strategic collaboration in May 2023 to transform clinical research by radically changing the way trials are designed and delivered. Discover a new article, co-written by Prof Sir Martin Landray, DCRI, Duke-Margolis Institute for Health Policy and Clinical Trials Transformation Initiative (CTTI), exploring opportunities to improve evidence generation in US-based clinical trials:  https://lnkd.in/e4UPSAbm The article discusses how to create a new infrastructure that brings trials closer to the diverse populations they serve. #clinicaltrials #clinicalresearch #diversity  

Thank you, Morgan Hanger, Executive Director of Clinical Trials Transformation Initiative (CTTI) for visiting us at Genentech! With Michelle Rohrer, Thomas Switzer, Ruma Bhagat, Ubong Peters, and Rachna Mittal, MBA, MSCS, PMP